In his 1982 paper, Ogus defined a class of cycles in the de Rham cohomology of smooth proper varieties over number fields. This notion is a crystalline analogue of `-adic Tate cycles. In the case of abelian varieties, this class includes all the Hodge cycles by the work of Deligne, Ogus, and Blasius. Ogus predicted that such cycles coincide with Hodge cycles for abelian varieties. In this paper...

UNLABELLED Peptide receptor radionuclide therapy (PRRT) is a promising treatment for patients with neuroendocrine tumors, giving rise to improved survival. Dosimetric calculations in relation to PRRT have been concentrated to normal organ dosimetry in order to limit side effects. However, the relation between the absorbed dose to the tumor and treatment response has so far not been established....

Abstract Background Extravasation of radiopharmaceuticals used for vectorized internal radiotherapy can lead to severe tissue damage (van der Pol et al., Eur J Nucl Med Mol Imaging 44:1234–1243, 2017). Clinical management these extravasations requires the preliminary estimation dose distribution in extravasation area. Data are scarce regarding literature. This work presents a methodology estima...

Introduction: In Peptide Receptor Radionuclide Therapy (PRRT), the administration of radionuclide such as Lu-177 label with a pharmaceutical agent useful to destroy the lesion. The amount of Lu-177 radioactivity administered to the patients is still not standardize and generally not more than 7.4 GBq per session due to the patient’s safety issues. The first cycle of Lu-177 is a...

Objective(s): The objectives of this work was to assess the benefits of the application of Physiologically Based Pharmacokinetic (PBPK) models in patients with different neuroendocrine tumours (NET) who were treatedwith Lu-177 DOTATATE. The model utilises clinical data on biodistribution of radiolabeled peptides (RLPs) obtained by whole body scintigraphy (WBS) of the patients.Methods: The blood...

BACKGROUND The diagnosis of Cushing disease is based on endocrinological pa-rameters, with no single test being specific. In some patients, dynamic thin-slice sellar magnetic resonance imaging fails to detect a pituitary tumor. OBJECTIVE The purpose of this study is to investigate the role of ectopic pituitary adenoma in this situation. METHODS In a retrospective chart review, 5 patients (6...

A 63-year-old woman presents for evaluation of chronic abdominal pain and diarrhea. Earlier was negative Helicobacter pylori or nonsteroidal anti-inflammatory drug use. Multiple esophagogastroduodenoscopies revealed severe esophagitis several duodenal ulcers despite a maximum dose omeprazole 2 years before diagnosis. Computed tomography endoscopic ultrasounds only inflammation benign hepatic cy...

In peptide receptor radionuclide therapy with 90Y-labeled DOTATATE, the kidney absorbed dose limits the maximum amount of total activity that can be safely administered in many patients. A higher tumor-to-kidney absorbed dose ratio might be achieved by optimizing the amount of injected peptide and activity, as recent studies have shown different degrees of receptor saturation for normal tissue ...