Dose-response analysis (DRA) has been a very popular topic within statistical estimation especially in biomedical areas. In addition to estimating the entire dose-response relationship, assessing the risk itself at a certain dose level has been of much interest in some applications, such as in estimating the maximum tolerated dose (MTD) in Phase I clinical trials. Although a variety of parametr...

introduction: effects of melatonin (mt) were comparatively examined on melanophores of isolated skin in adults and tadpole’s tailfin of a frog rana cyanophlyctis. mt is generally considered as a potent melanophores aggregating hormone besides regulating the sleep wake cycle in vertebrates. methods: melanophore size index (msi) was chosen as a recording parameter of the responses. concentration-...

AIMS To examine the dose-response relation of inhaled fluticasone for both efficacy and adrenal function in children with asthma. METHODS Systematic review of double blind randomised dose-response studies of fluticasone in children of at least 4 weeks duration. MAIN OUTCOME MEASURES FEV1, morning peak expiratory flow, night awakenings, beta agonist use, major exacerbations, 12 or 24 hour ur...

We examined the effect of estrogen on pressor responses to an alpha1-adrenoreceptor agonist (phenylephrine) in conscious female Wistar-Kyoto rats. At the age of 11 weeks, rats underwent ovariectomy or a sham procedure. At the age of 15 weeks, ovariectomized (OVX) rats received intramuscular injection of estradiol valerate (EV) 5 microg (OVX+EV 5 microg group; n = 6), EV 25 microg (OVX+EV 25 mic...

Asthma is an inflammatory disorder of the airways and inhaled corticosteroids are the most effective agents in controlling the disease process. The corticosteroid-dose response curve has traditionally been thought of as being flat, i.e. plateaus early, with no further therapeutic response with increasing dose of medication. This is only true for mild asthma and the improvement in airway calibre...

  Numerous studies conducted in laboratory animals and humans indicate that angiotensin converting enzyme inhibitors reinforce memory and learning. In this paper we study the effect of injection of enalapril into the cerebral ventricles on spatial memory of white mice in the double- y maze, following the induction of an Alzheimer- like amnestic model with scopolamine. To estimate the duration o...

A mathematical model was created to examine how xenobiotic ligands that bind to nuclear receptor proteins may affect transcriptional activation of hormone-regulated genes. The model included binding of the natural ligand (e.g. hormone) and xenobiotic ligands to the receptor, binding of the liganded receptor to receptor-specific DNA response sequences, binding of co-activator or co-repressor pro...

background combining different analgesic drugs for improvement of drug efficacy is a recommended strategy intended to achieve the optimal therapeutic effects. objectives the purpose of the present study was to assess the nature of the interaction between ascorbic acid and two analgesic drugs, morphine and tramadol. materials and methods the analgesic activity was assessed by the acetic acid wri...