Downlo ticular germ cell tumors (TGCT) originate from germ cells. The 129-Ter and M19 (129.MOLF-Chr19 mic) mouse strains have extremely high incidences of TGCTs. We found that the expression levels of coded splicing factor 1 (SF1) can modulate the incidence of TGCTs. We generated mice with inactivated null mice (Sf1−/−) died before birth. Mice with one intact allele of Sf1 (Sf1+/−) were viable ...

The radiosensitizing potential of gemcitabine (2',2'-difluoro-2'-deoxycytidine) was studied in combination with pulsed low dose-rate irradiation. The experiments were carried out with a human lung carcinoma cell line SW1573. These were irradiated at pulsed low dose rate (p-LDR); the average dose rate was 1 Gy/h. In the experiments with gemcitabine, this drug was applied for 24 h at a concentrat...

In this letter we propose an extension of the Dissipating Energy Flow (DEF) method for locating sources forced oscillations (FOs), based on energy function constructed by complex integral approach, which call Complex DEF (CDEF). To trace FO, study scalar projection CDEF in a specific direction plane. We show simulated cases that alternative has good performance where original fails.

A criterion for finding a configuration of jets for a given multiparticle event: • is derived uniquely from minimum formal input; • guarantees minimal distortion of physical information in the transition from particles to jets; • is optimally stable with respect to data errors; • does not restrict geometric shape of jets; • allows jets to share particles; • amounts to finding a matrix via minim...

The effects of vitamin A (VitA) deficiency on the host intestinal immune response and disease susceptibility to coccidiosis were investigated in broiler chickens following oral infection with Eimeria acervulina (EA). Day-old male broilers were fed milo-soybean meal diets either with 8,000 IU VitA/kg feed (CONT) or without added VitA (A-DEF). At 25 d, a group of randomly selected birds from each...

the thermo-hydraulic behavior of the air flow over a two dimensional ribbed channel wasnumerically investigated in various rib-width ratio configurations (b/h=0.5-1.75) atdifferent reynolds numbers, ranging from 6000 to 18000. the capability of differentturbulence models, including standard k-ε, rng k-ε, standard k-ω, and sst k-ω, inpredicting the heat transfer rate was compared with the experi...

The anticoagulant activation of the serpin antithrombin by heparin pentasaccharide DEFGH was previously shown to involve trisaccharide DEF first binding and inducing activation of the serpin, followed by disaccharide GH binding and stabilizing the activated state [Petitou et al. (1997) Glycobiology 7, 323-327; Desai et al. (1998) J. Biol. Chem. 273, 7478-7487]. In the present study, the role of...

Let X be an irreducible symplectic manifold and Def(X) the Kuranishi space. Assume that X admits a Lagrangian fibration. We prove that X can be deformed preserving a Lagrangian fibration. More precisely, there exists a smooth hypersurface H of Def(X) such that the restriction family X ×Def(X) H admits a family of Lagrangian fibrations over H.

Conformational activation of antithrombin is a critical mechanism for the inhibition of factor Xa, a proteinase of the blood coagulation cascade, and is typically achieved with heparin, a polyanionic polysaccharide clinically used for anticoagulation. Although numerous efforts have been directed toward the design of better activators, a fundamental tenet of these studies has been the assumed re...