Risk assessment formulas are often distinguished from dose-response models by being rough but necessary. The evaluation of these rough formulas is described here, using the example of mixture risk assessment. Two conditions make the dose-response part of mixture risk assessment difficult, lack of data on mixture dose-response relationships, and the need to address risk from combinations of chem...

Parents often overreport adherence to asthma treatment regimens making accurate assessment of medication adherence in clinical practice difficult. This study was conducted to compare two adherence assessment methods clinicians may choose from when assessing patient inhaled corticosteroid (ICS) adherence: parental report and dose counter measurements of metered-dose inhaler (MDI) actuation. Part...

Radiation dose assessment in advanced synchrotron radiation facility is challenging due to the complexity and uncertainties of radiation source terms induced by high energy particle accelerator. Shanghai Synchrotron Radiation Facility (SSRF) is the first third-generation synchrotron facility in China, which was completed in 2009. Radiation dose assessment for workers at SSRF Beam lines is highl...

This study considers fundamental methods in occupational risk assessment of exposure to airborne engineered nanomaterials. We discuss characterization of particle emissions, exposure assessment, hazard assessment with in vitro studies, and risk range characterization using calculated inhaled doses and dose-response translated to humans from in vitro studies. Here, the methods were utilized to a...

introduction: ionizing radiation induces various kinds of dna damage in which may lead to chromosomal aberrations (ca). inspite of growing importance in the risk assessment, the dose yield kinetics of ca and their implications for dose assessment are not well established in exposures to low level radiation. in the present study, cytochalasin-b blocked micronucleus assay and metaphase analysis w...

An international workshop was held in 2006 to evaluate experimental techniques for hazard identification and hazard characterization of sensitizing agents in terms of their ability to produce data, including dose-response information, to inform risk assessment. Human testing to identify skin sensitizers is discouraged for ethical reasons. Animal-free alternatives, such as quantitative structure...

introduction: polymer gels are modern dosimeters providing three dimensional dose distributions. these dosimeters can be used in brachytherapy in which the tumor dimension is relatively small and the dose gradient is high. in this study, the ability of the magica polymer gel was investigated for assessing the absolute dose values as well as the dose distribution of low dose rate (ldr) ir-192 wi...

INTRODUCTION Moderate to deep sedation is generally used for endoscopic retrograde cholangiopancreatography (ERCP). The depth of sedation is usually judged by clinical assessment and electroencephalography-guided monitoring. The aim of this study was to compare the clinical efficacy of clinical assessment and Narcotrend(TM) monitoring during deep-sedated ERCP. METHODS One hundred patients who...

OBJECTIVE Different technical and procedural methods have been introduced to develop low radiation dose protocols in neurointerventional examinations. We investigated the feasibility of minimizing radiation exposure dose by simply decreasing the detector dose during cerebral DSA and evaluated the comparative level of image quality using both subjective and objective methods. METHODS In a pros...