For high-risk breast cancer patients with positive axillary lymph nodes, dose-dense every-two-week epirubicin/cyclophosphamide-paclitaxel (ddEC-P) regimen is the optimal postoperative adjuvant therapy. However, this regimen is limited by the grade 3/4 neutropenia and febrile neutropenia (FN). There is an urgent need to explore the efficacy, safety and proper dosage of PEGylated granulocyte colo...

Ten patients with congenital adrenal hyperplasia (three males, seven females; aged 12-29 years) had their usual glucocorticoid treatment changed to dexamethasone in three crossover dosage regimens. A starting dose of 5 micrograms/kg/day is suggested but as no one dose regimen resulted in adequate control the timing of the dose must be decided for each patient.

BACKGROUND This study aimed to evaluate the population pharmacokinetics of digoxin in Japanese patients and establish a dosage regimen based on the pharmacokinetic data. METHODS We analyzed 287 serum digoxin samples from 192 individuals by using the nonlinear mixed effects model. We used simulations to optimize the dosage regimen of digoxin to achieve a high likelihood of the target concentra...

PURPOSE The clinical and economic outcomes of a meropenem dosage strategy based on pharmacodynamic concepts are retrospectively reviewed. METHODS The medical records of all patients receiving at least one day of meropenem at a large teaching hospital during 2002 were reviewed. Patients were included if they were clinically evaluable, had no prior successful antibiotic therapy, and received a ...

BACKGROUND Tumor necrosis might be a consequence of innate sensitivity of tumor cells to changed dosage instead of the increased dosage of chemotherapeutics in the treatment of osteosarcoma patients. AIM To explore whether dose-intensive regimen was a better treatment method than dose-control chemotherapy for high-grade osteosarcoma patients. MATERIALS AND METHODS The data of the included s...

Introduction Low dosage insulin regimens for diabetic "comas" have recently attracted considerable attention (Alberti, Hockaday and Turner, 1973; Page et al, 1974; Kidson et al, 1974; Semple, White and Manderson, 1974). These regimans have all originated from established diabetic centres, however the simplicity of these regimens, especially the intra muscular regimen (Alberti et al, 1973), woul...

Significant improvements in hematopoietic stem cell transplantation (HSCT) with haploidentical family donors (HFD) have confirmed its therapeutic role in severe aplastic anemia (SAA) and led to the evolution of treatment algorithms. However, the optimal conditioning regimen for HFD-HSCT remains undefined, especially the dosage of cyclophosphamide (Cy). A total of 77 patients with SAA from two r...

The purpose of the present study was to establish a pharmacokinetic/pharmacodynamic (PK/PD) modeling approach for the dosage schedule design and decreasing the emergence of drug-resistant bacteria. The minimal inhibitory concentration (MIC) of 929 Escherichia coli isolates from broilers to enrofloxacin and ciprofloxacin was determined following CLSI guidance. The MIC50 was calculated as the pop...

Serum drug concentrations have commonly been described in terms of therapeutic ranges within which most patients have a therapeutic effect and a low incidence of toxicity. However, truly individualized drug dosage regimens cannot be developed without first setting a specific individualized target goal, such as a target serum drug concentration, at a desired target time after the dose (usually a...

OBJECTIVE To develop guidelines for selection of antiepileptic drugs (AEDs) among people with HIV/AIDS. METHODS The literature was systematically reviewed to assess the global burden of relevant comorbid entities, to determine the number of patients who potentially utilize AEDs and antiretroviral agents (ARVs), and to address AED-ARV interactions. RESULTS AND RECOMMENDATIONS AED-ARV adminis...