Hematopoietic chimerism is known to promote donor-specific organ allograft tolerance; however, clinical translation has been impeded by the requirement for toxic immunosuppression and large doses of donor bone marrow (BM) cells. Here, we investigated in mice whether durable chimerism might be enhanced by pre-treatment of the recipient with liposomal clodronate, a macrophage depleting agent, wit...

An increasing number of Australian parents of donor-conceived children are making contact with their child's donor relatives prior to their child reaching the age of majority. This process, often referred to as 'donor linking', can be achieved in Australia through either formal or informal mechanisms. Formal mechanisms exist in three states, each of which has legislation enabling donor linking ...

The annual number of liver transplantation (LT) in Korea has continuously increased, mainly due to the explosive rise in the number of living donor liver transplants (LDLT) (Fig. 1A) [1]. However, LT cannot keep pace with the increase in the size of the waiting list in Korea despite the recent gradual boost in deceased donor numbers (Fig. 1B) [1]. Therefore, expanding the liver donor pool has a...

INTRODUCTION The goal of the Eurotransplant renal allocation scheme is to provide every patient on the waiting list with a reasonably balanced opportunity for a donor offer. New initiatives were taken in order to maximize donor usage while maintaining a successful transplant outcome. METHODS Two Eurotransplant projects were launched in order to accommodate changes in donor and recipient profi...

Renal transplantation improves survival of patients with end-stage kidney disease (ESKD) (Wolfe, McCullough et al. 2009). In most countries, including the United States and Australia, there continues to be a growing disparity between the limited availability of deceased-donor kidneys compared to potential transplant candidates. In contrast, livedonor kidney transplantation has been steadily inc...

The widely held view that transfused bone marrow cells will not proliferate in normal mice, not exposed to irradiation or other forms of bone marrow ablation, was reinvestigated. Forty million bone marrow cells from male donors were given to female recipients on each of 5 consecutive days, 5 to 10 times the number customarily used in the past. When the recipients were examined 2-13 weeks after ...

Aims: The purpose of this study was to investigate the role of spiritual well-being and demographic characteristics in signing the donor card. Instrument & Methods: This cross-sectional study was conducted in Hamadan in 2018. Six hundred employees from 57 offices (out of 60) were selected using a random sampling method. Data gathering was carried out using a self-administered questionnaire. Th...

purpose: to report the possible transmission of zygomycetes infection by a corneal graft harvested from a donor with signs of trauma to the orbital region to a keratoconic patient who underwent deep anterior lamellar keratoplasty (dalk). case report: a 19-year-old keratoconic man underwent dalk in the right eye. the corneal graft was harvested from a donor with signs of orbital trauma. on posto...

Changes in organ allocation policy in 2002 reduced the number of adult patients on the liver transplant waiting list, changed the characteristics of transplant recipients and increased the number of patients receiving simultaneous liver-kidney transplantation (SLK). The number of liver transplants peaked in 2006 and declined marginally in 2007 and 2008. During this period, there was an increase...

During the last few years, the number of living donor kidney transplants has increased and this form of transplantation is currently the only option in some patients. We report two cases of living donor kidney transplantation in which the donor carried monoclonal gammopathy of undetermined significance. Neither of the two receptors has developed complications at 42 and 36 months after transplan...