نتایج جستجو برای: dna repair gene

تعداد نتایج: 1565035  

Journal: :Cell 1995
Tracy Blunt Nicholas J Finnie Guillermo E Taccioli Graeme C.M Smith Jocelyne Demengeot Tanya M Gottlieb Ryushin Mizuta A. J Varghese Frederick W Alt Penny A Jeggo Stephen P Jackson

Murine cells homozygous for the severe combined immune deficiency mutation (scid) and V3 mutant hamster cells fall into the same complementation group and show similar defects in V(D)J recombination and DNA double-stranded break repair. Here we show that both cell types lack DNA-dependent protein kinase (DNA-PK) activity owing to defects in DNA-PKcs, the catalytic subunit of this enzyme. Furthe...

2012
BIN-CHUAN JI CHIEN-CHIH YU SU-TSO YANG TE-CHUN HSIA JAI-SING YANG KUANG-CHI LAI YANG-CHING KO JEN-JYH LIN TUNG-YUAN LAI JING-GUNG CHUNG

It has been shown that deguelin, one of the compounds of rotenoids from flavonoid family, induced cytotoxic effects through induction of cell cycle arrest and apoptosis in many types of human cancer cell lines, but deguelin-affected DNA damage and repair gene expression (mRNA) are not clarified yet. We investigated the effects of deguelin on DNA damage and associated gene expression in human lu...

2016
Hanna Romanowicz Magdalena Bryś Ewa Forma Beata Smolarz

There are several biochemical pathways that can lead to cancerogenesis, one of which involves DNA damage induced by exogenous carcinogens or by endogenous metabolic processes. The double-strand break DNA repair pathway, including XRCC2 gene, is implicated in maintaining genomic stability and therefore could affect cancer risk. Common genetic polymorphisms in DNA repair genes might affect protei...

2004
Hai-Ri Li Elena I. Shagisultanova Kentaro Yamashita Zhe Piao Manuel Perucho Sergei R. Malkhosyan

Genetic or epigenetic inactivation of DNA mismatch repair genes results in a strong mutator phenotype, known as the microsatellite mutator phenotype or microsatellite instability (MSI). This mutator phenotype causes mutations in genes responsible for the regulation of cell growth and survival/death and thus promotes the development and progression of tumors. In addition to such tumorigenic lesi...

Journal: :Cancer research 2004
Hai-Ri Li Elena I Shagisultanova Kentaro Yamashita Zhe Piao Manuel Perucho Sergei R Malkhosyan

Genetic or epigenetic inactivation of DNA mismatch repair genes results in a strong mutator phenotype, known as the microsatellite mutator phenotype or microsatellite instability (MSI). This mutator phenotype causes mutations in genes responsible for the regulation of cell growth and survival/death and thus promotes the development and progression of tumors. In addition to such tumorigenic lesi...

Journal: :Genetics 1999
K J Hillers F W Stahl

In Saccharomyces cerevisiae, some gene loci manifest gradients in the frequency of aberrant segregation in meiosis, with the high end of each gradient corresponding to a hotspot for DNA double-strand breaks (DSBs). The slope of a gradient is reduced when mismatch repair functions fail to act upon heteroduplex DNA-aberrant segregation frequencies at the low end of the gradient are higher in the ...

Journal: :PeerJ 2021

Glioblastoma, a grade IV astrocytoma, has poor survival rate in part due to ineffective treatment options available. These tumours are heterogeneous with areas of low oxygen levels, termed hypoxic regions. Many intra-cellular signalling pathways, including DNA repair, can be altered by hypoxia. Since damage induction and subsequent activation repair mechanisms is the cornerstone glioblastoma tr...

2011
Kenta Masuda Kouji Banno Megumi Yanokura Yusuke Kobayashi Iori Kisu Arisa Ueki Asuka Ono Nana Asahara Hiroyuki Nomura Akira Hirasawa Nobuyuki Susumu Daisuke Aoki

Some cases of endometrial cancer are associated with a familial tumor and are referred to as hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome). Lynch syndrome is thought to be induced by germline mutation of the DNA mismatch repair (MMR) gene. An aberration in the MMR gene prevents accurate repair of base mismatches produced during DNA replication. This phenomenon can lead to ...

2011
Anne Stary Alain Sarasin

Initiates DNA repair by binding to damaged sites with various affinities, depending upon the chemical structure of the lesion. Two proteins have been identified and implicated in (one of) the first steps of Nucleotide Excision Repair (NER), i.e. the recognition of lesions in the DNA: the XPA gene product and the XPC gene product. Cells from XPA patients are extremely sensitive to UV and have ve...

Journal: :Cell 1995
Sean M Baker C.Eric Bronner Lin Zhang Annemieke W Plug Merrilee Robatzek Gwynedd Warren Eileen A Elliott Jian Yu Terry Ashley Norman Arnheim Richard A Flavell R.Michael Liskay

Using gene targeting in embryonic stem cells, we have derived mice with a null mutation in a DNA mismatch repair gene homolog, PMS2. We observed microsatellite instability in the male germline, in tail, and in tumor DNA of PMS2-deficient animals. We therefore conclude that PMS2 is involved in DNA mismatch repair in a variety of tissues. PMS2-deficient animals appear prone to sarcomas and lympho...

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