نتایج جستجو برای: dna mutational analysis

تعداد نتایج: 3221390  

Journal: :Journal of Biological Chemistry 2003

Journal: :Nature communications 2016
Jane Merlevede Nathalie Droin Tingting Qin Kristen Meldi Kenichi Yoshida Margot Morabito Emilie Chautard Didier Auboeuf Pierre Fenaux Thorsten Braun Raphael Itzykson Stéphane de Botton Bruno Quesnel Thérèse Commes Eric Jourdan William Vainchenker Olivier Bernard Noemie Pata-Merci Stéphanie Solier Velimir Gayevskiy Marcel E Dinger Mark J Cowley Dorothée Selimoglu-Buet Vincent Meyer François Artiguenave Jean-François Deleuze Claude Preudhomme Michael R Stratton Ludmil B Alexandrov Eric Padron Seishi Ogawa Serge Koscielny Maria Figueroa Eric Solary

The cytidine analogues azacytidine and 5-aza-2'-deoxycytidine (decitabine) are commonly used to treat myelodysplastic syndromes, with or without a myeloproliferative component. It remains unclear whether the response to these hypomethylating agents results from a cytotoxic or an epigenetic effect. In this study, we address this question in chronic myelomonocytic leukaemia. We describe a compreh...

2002
Seth Bullock

As a population evolves, its members are under selection both for rate of reproduction (fitness) and mutational robustness. For those using evolutionary algorithms as optimisation techniques, this second selection pressure can sometimes be beneficial, but it can also bias evolution in unwelcome and unexpected ways. Here, the role of selection for mutational robustness in driving adaptation on n...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Dee R Denver Peter C Dolan Larry J Wilhelm Way Sung J Ignacio Lucas-Lledó Dana K Howe Samantha C Lewis Kazu Okamoto W Kelley Thomas Michael Lynch Charles F Baer

Knowledge of mutation processes is central to understanding virtually all evolutionary phenomena and the underlying nature of genetic disorders and cancers. However, the limitations of standard molecular mutation detection methods have historically precluded a genome-wide understanding of mutation rates and spectra in the nuclear genomes of multicellular organisms. We applied two high-throughpu...

2015
Wilson Leung Christopher D. Shaffer Laura K. Reed Sheryl T. Smith William Barshop William Dirkes Matthew Dothager Paul Lee Jeannette Wong David Xiong Han Yuan James E. J. Bedard Joshua F. Machone Seantay D. Patterson Amber L. Price Bryce A. Turner Srebrenka Robic Erin K. Luippold Shannon R. McCartha Tezin A. Walji Chelsea A. Walker Kenneth Saville Marita K. Abrams Andrew R. Armstrong William Armstrong Robert J. Bailey Chelsea R. Barberi Lauren R. Beck Amanda L. Blaker Christopher E. Blunden Jordan P. Brand Ethan J. Brock Dana W. Brooks Marie Brown Sarah C. Butzler Eric M. Clark Nicole B. Clark Ashley A. Collins Rebecca J. Cotteleer Peterson R. Cullimore Seth G. Dawson Carter T. Docking Sasha L. Dorsett Grace A. Dougherty Kaitlyn A. Downey Andrew P. Drake Erica K. Earl Trevor G. Floyd Joshua D. Forsyth Jonathan D. Foust Spencer L. Franchi James F. Geary Cynthia K. Hanson Taylor S. Harding Cameron B. Harris Jonathan M. Heckman Heather L. Holderness Nicole A. Howey Dontae A. Jacobs Elizabeth S. Jewell Maria Kaisler Elizabeth A. Karaska James L. Kehoe Hannah C. Koaches Jessica Koehler Dana Koenig Alexander J. Kujawski Jordan E. Kus Jennifer A. Lammers Rachel R. Leads Emily C. Leatherman Rachel N. Lippert Gregory S. Messenger Adam T. Morrow Victoria Newcomb Haley J. Plasman Stephanie J. Potocny Michelle K. Powers Rachel M. Reem Jonathan P. Rennhack Katherine R. Reynolds Lyndsey A. Reynolds Dong K. Rhee Allyson B. Rivard Adam J. Ronk Meghan B. Rooney Lainey S. Rubin Luke R. Salbert Rasleen K. Saluja Taylor Schauder Allison R. Schneiter Robert W. Schulz Karl E. Smith Sarah Spencer Bryant R. Swanson Melissa A. Tache Ashley A. Tewilliager Amanda K. Tilot Eve VanEck Matthew M. Villerot Megan B. Vylonis David T. Watson Juliana A. Wurzler Lauren M. Wysocki Monica Yalamanchili Matthew A. Zaborowicz Julia A. Emerson Carlos Ortiz Frederic J. Deuschle Lauren A. DiLorenzo Katie L. Goeller Christopher R. Macchi Sarah E. Muller Brittany D. Pasierb Joseph E. Sable Jessica M. Tucci Marykathryn Tynon David A. Dunbar Levent H. Beken Alaina C. Conturso Benjamin L. Danner Gabriella A. DeMichele Justin A. Gonzales Maureen S. Hammond Colleen V. Kelley Elisabeth A. Kelly Danielle Kulich Catherine M. Mageeney Nikie L. McCabe Alyssa M. Newman Lindsay A. Spaeder Richard A. Tumminello Dennis Revie Jonathon M. Benson Michael C. Cristostomo Paolo A. DaSilva Katherine S. Harker Jenifer N. Jarrell Luis A. Jimenez Brandon M. Katz William R. Kennedy Kimberly S. Kolibas Mark T. LeBlanc Trung T. Nguyen Daniel S. Nicolas Melissa D. Patao Shane M. Patao Bryan J. Rupley Bridget J. Sessions Jennifer A. Weaver Anya L. Goodman Erica L. Alvendia Shana M. Baldassari Ashley S. Brown Ian O. Chase Maida Chen Scott Chiang Avery B. Cromwell Ashley F. Custer Tia M. DiTommaso Jad El-Adaimi Nora C. Goscinski Ryan A. Grove Nestor Gutierrez Raechel S. Harnoto Heather Hedeen Emily L. Hong Barbara L. Hopkins Vilma F. Huerta Colin Khoshabian Kristin M. LaForge Cassidy T. Lee Benjamin M. Lewis Anniken M. Lydon Brian J. Maniaci Ryan D. Mitchell Elaine V. Morlock William M. Morris Priyanka Naik Nicole C. Olson Jeannette M. Osterloh Marcos A. Perez Jonathan D. Presley Matt J. Randazzo Melanie K. Regan Franca G. Rossi Melanie A. Smith Eugenia A. Soliterman Ciani J. Sparks Danny L. Tran Tiffany Wan Anne A. Welker Jeremy N. Wong Aparna Sreenivasan Jim Youngblom Andrew Adams Justin Alldredge Ashley Bryant David Carranza Alyssa Cifelli Kevin Coulson Calise Debow Noelle Delacruz Charlene Emerson Cassandra Farrar Don Foret Edgar Garibay John Gooch Michelle Heslop Sukhjit Kaur Ambreen Khan Van Kim Travis Lamb Peter Lindbeck Gabi Lucas Elizabeth Macias Daniela Martiniuc Lissett Mayorga Joseph Medina Nelson Membreno Shady Messiah Lacey Neufeld San Francisco Nguyen Zachary Nichols George Odisho Daymon Peterson Laura Rodela Priscilla Rodriguez Vanessa Rodriguez Jorge Ruiz Will Sherrill Valeria Silva Jeri Sparks Geeta Statton Ashley Townsend Isabel Valdez Mary Waters Kyle Westphal Stacey Winkler Joannee Zumkehr Randall J. DeJong Arlene J. Hoogewerf Cheri M. Ackerman Isaac O. Armistead Lara Baatenburg Matthew J. Borr Lindsay K. Brouwer Brandon J. Burkhart Kelsey T. Bushhouse Lejla Cesko Tiffany Y. Y. Choi Heather Cohen Amanda M. Damsteegt Jess M. Darusz Cory M. Dauphin Yelena P. Davis Emily J. Diekema Melissa Drewry Michelle E. M. Eisen Hayley M. Faber Katherine J. Faber Elizabeth Feenstra Isabella T. Felzer-Kim Brandy L. Hammond Jesse Hendriksma Milton R. Herrold Julia A. Hilbrands Emily J. Howell Sarah A. Jelgerhuis Timothy R. Jelsema Benjamin K. Johnson Kelly K. Jones Anna Kim Ross D. Kooienga Erika E. Menyes Eric A. Nollet Brittany E. Plescher Lindsay Rios Jenny L. Rose Allison J. Schepers Geoff Scott Joshua R. Smith Allison M. Sterling Jenna C. Tenney Chris Uitvlugt Rachel E. VanDyken Marielle VanderVennen Samantha Vue Nighat P. Kokan Kwabea Agbley Sampson K. Boham Daniel Broomfield Kayla Chapman Ali Dobbe Ian Dobbe William Harrington Marwan Ibrahem Andre Kennedy Chad A. Koplinsky Cassandra Kubricky Danielle Ladzekpo Claire Pattison Roman E. Ramirez Lucia Wande Sarah Woehlke Matthew Wawersik Elizabeth Kiernan Jeffrey S. Thompson Roxanne Banker Justina R. Bartling Chinmoy I. Bhatiya Anna L. Boudoures Lena Christiansen Daniel S. Fosselman Kristin M. French Ishwar S. Gill Jessen T. Havill Jaelyn L. Johnson Lauren J. Keny John M. Kerber Bethany M. Klett Christina N. Kufel Francis J. May Jonathan P. Mecoli Callie R. Merry Lauren R. Meyer Emily G. Miller Gregory J. Mullen Katherine C. Palozola Jacob J. Pfeil Jessica G. Thomas Evan M. Verbofsky Eric P. Spana Anant Agarwalla Julia Chapman Ben Chlebina Insun Chong I.N. Falk John D. Fitzgibbons Harrison Friedman Osagie Ighile Andrew J. Kim Kristin A. Knouse Faith Kung Danny Mammo Chun Leung Ng Vinayak S. Nikam Diana Norton Philip Pham Jessica W. Polk Shreya Prasad Helen Rankin Camille D. Ratliff Victoria Scala Nicholas U. Schwartz Jessica A. Shuen Amy Xu Thomas Q. Xu Yi Zhang Anne G. Rosenwald Martin G. Burg Stephanie J. Adams Morgan Baker Bobbi Botsford Briana Brinkley Carter Brown Shadie Emiah Erica Enoch Chad Gier Alyson Greenwell Lindsay Hoogenboom Jordan E. Matthews Mitchell McDonald Amanda Mercer Nicholaus Monsma Kristine Ostby Alen Ramic Devon Shallman Matthew Simon Eric Spencer Trisha Tomkins Pete Wendland Anna Wylie Michael J. Wolyniak Gregory M. Robertson Samuel I. Smith Justin R. DiAngelo Eric D. Sassu Satish C. Bhalla Karim A. Sharif Tenzin Choeying Jason S. Macias Fareed Sanusi Karvyn Torchon April E. Bednarski Consuelo J. Alvarez Kristen C. Davis Carrie A. Dunham Alaina J. Grantham Amber N. Hare Jennifer Schottler Zackary W. Scott Gary A. Kuleck Nicole S. Yu Marian M. Kaehler Jacob Jipp Paul J. Overvoorde Elizabeth Shoop Olivia Cyrankowski Betsy Hoover Matt Kusner Devry Lin Tijana Martinov Jonathan Misch Garrett Salzman Holly Schiedermayer Michael Snavely Stephanie Zarrasola Susan Parrish Atlee Baker Alissa Beckett Carissa Belella Julie Bryant Turner Conrad Adam Fearnow Carolina Gomez Robert A. Herbstsomer Sarah Hirsch Christen Johnson Melissa Jones Rita Kabaso Eric Lemmon Carolina Marques dos Santos Vieira Darryl McFarland Christopher McLaughlin Abbie Morgan Sepo Musokotwane William Neutzling Jana Nietmann Christina Paluskievicz Jessica Penn Emily Peoples Caitlin Pozmanter Emily Reed Nichole Rigby Lasse Schmidt Micah Shelton Rebecca Shuford Tiara Tirasawasdichai Blair Undem Damian Urick Kayla Vondy Bryan Yarrington Todd T. Eckdahl Jeffrey L. Poet Alica B. Allen John E. Anderson Jason M. Barnett Jordan S. Baumgardner Adam D. Brown Jordan E. Carney Ramiro A. Chavez Shelbi L. Christgen Jordan S. Christie Andrea N. Clary Michel A. Conn Kristen M. Cooper Matt J. Crowley Samuel T. Crowley Jennifer S. Doty Brian A. Dow Curtis R. Edwards Darcie D. Elder John P. Fanning Bridget M. Janssen Anthony K. Lambright Curtiss E. Lane Austin B. Limle Tammy Mazur Marly R. McCracken Alexa M. McDonough Amy D. Melton Phillip J. Minnick Adam E. Musick William H. Newhart Joseph W. Noynaert Bradley J. Ogden Michael W. Sandusky Samantha M. Schmuecker Anna L. Shipman Anna L. Smith Kristen M. Thomsen Matthew R. Unzicker William B. Vernon Wesley W. Winn Dustin S. Woyski Xiao Zhu Chunguang Du Caitlin Ament Soham Aso

The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the...

2012
Peter Vd’ačný William A. Bourland William Orsi Slava S. Epstein Wilhelm Foissner

The class Litostomatea is a highly diverse ciliate taxon comprising hundreds of free-living and endocommensal species. However, their traditional morphology-based classification conflicts with 18S rRNA gene phylogenies indicating (1) a deep bifurcation of the Litostomatea into Rhynchostomatia and Haptoria+Trichostomatia, and (2) body polarization and simplification of the oral apparatus as main...

Journal: :International microbiology : the official journal of the Spanish Society for Microbiology 2008
Fouzia Haider James K Lithgow Melanie R Stapleton Valia A Norte Ruth E Roberts Jeffrey Green

The Salmonella regulatory protein SlyA is implicated in virulence, survival in macrophages and resistance to oxidative stress and anti-microbial peptides. SlyA is a member of the MarR family of winged-helix transcription factors. Systematic mutational analysis of the SlyA operator sequence and of the predicted DNA-binding region of SlyA shows that no single base pair in the palindromic SlyA ope...

Journal: :Biochimica et Biophysica Acta (BBA) - Biomembranes 2011

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