We have studied the effects of lipoxygenase inhibition and metabolite addition of HL-60 cells induced to differentiate. When HL-60 are induced by dimethyl sulfoxide (DMSO) in the presence of an inhibitor of lipoxygenase, caffeic acid, there is a marked change from the expected phenotype of mature granulocytes to a population composed predominantly of mature monocytes. (DMSO alone: 54% granulocy...

Exposure of HepG2 cells to 1 % (v/v) dimethyl sulfoxide (DMSO), an effective free radical scavenger, for 24 h resulted in a 2-fold increase in the levels of apolipoprotein (apo) A-I mRNA and secreted protein, with no significant change in apoA-11, apoB, and apoE mRNA and protein levels. The induction of apoA-I was accompanied by a 50% increase in secreted HDL. Nuclear run-off assays indicated t...

Dimethyl sulfoxide(DMSO) is frequently used as a solvent for antifungal drugs in various studies to determine their MICs. Reports on comparative evaluation of methods for the susceptibility testing of antifungal drugs have shown there is poor agreement among methods. Besides other factors which could cause variability in the results, one important factor might be the effect of DMSO on the growt...

PURPOSE This study was undertaken to investigate whether use of an adhesive penetration enhancer, dimethyl sulfoxide (DMSO), improves bond stability of fiber posts to root dentin using two two-step etch-and-rinse resin cements. MATERIALS AND METHODS Forty human maxillary central incisor roots were randomly divided into 4 groups after endodontic treatment and post space preparation, based on t...

We performed molecular dynamics simulations on dipalmitoylphosphatidylcholine (DPPC)/dimethylsulfoxide (DMSO) system that has the same lipid:solvent weight ratio as in our previous simulation done on DPPC/water. We did not observe a large change in the size of DPPC membrane when the solvent was changed from water to DMSO. Also, we did not observe that a large number of DMSO molecules is permeat...

INTRODUCTION Dimethyl sulfoxide (DMSO) is a chemical often used as a solvent for water-insoluble drugs. In this study, we evaluated the effect of intracerebroventricular (ICV) administration of DMSO on neural response characteristics (in 1200-1500 μm depth) of the rat barrel cortex. METHODS DMSO solution was prepared in 10% v/v concentration and injected into the lateral ventricle of rats. Ne...

background adipose tissue mesenchymal stem cells (at-mscs) are suitable choices in treatment of liver associated diseases. dimethyl sulfoxide (dmso) is an amphipathic molecule with potential of delivering both lipophilic and hydrophilic agents into cells. few protocols used dmso for induction of at-mscs towards hepatocyte like cells but the effect of dmso on hepatogenic differentiation were not...

Insulin increases muscle and fat cell glucose uptake by inducing the translocation of glucose transporter GLUT4 from intracellular compartments to the plasma membrane. Here, we have demonstrated that in 3T3-L1 adipocytes, DMSO at concentrations higher than 7.5% augmented cell surface GLUT4 levels in the absence and presence of insulin, but that at lower concentrations, DMSO only enhanced GLUT4 ...

Various exogenous compounds, for example, the drugs bupropione and propofol, but also various cytostatics, are metabolized in the liver by the enzyme cytochrome P450 (P450) CYP2B6. Transcription from the CYP2B6 gene is regulated mainly via the transcription factors constitutive androstane receptor (CAR) and pregnane-Xreceptor (PXR). Most hepatic cell lines express no or only low levels of CYP2B...

The reaction of cis,fac-[RuCl2(dmso-S)3(dmso-O)], 1, with different azole (L) ligands leads to new [RuCl2(L)(dmso-S)3] compounds (L = CH3-pz-H, 2; NO2-pz-H, 3; CF3-pz-H, 4 and Br-Hind, 5). Complexes 2-5 have been characterized by analytical, spectroscopic and electrochemical techniques as well as by monocrystal X-ray diffraction analysis. Upon oxidation to Ru(iii) the complexes undergo linkage ...