The supernumerary chromosome 21 in Down syndrome differentially affects the methylation statuses at CpG dinucleotide sites and creates genome-wide transcriptional dysregulation of parental alleles, ultimately causing diverse pathologies. At present, it is unknown whether those effects are dependent or independent of the parental origin of the nondisjoined chromosome 21. Linkage analysis is a st...

The multi-carrier multi-access technique is widely adopt in future wireless communication systems, such as IEEE 802.16m and 3GPP LTE-A. The channel resources allocation in multi-carrier multi-access channel, which can greatly improve the system throughput with QoS assurance, thus attracted much attention from both academia and industry. There lacks, however, an analytic framework with a compreh...

With the advent of all-sky Hα surveys it is possible to determine a reliable free-free template of the diffuse interstellar medium (Dickinson, Davies & Davis 2003) which can be used in conjunction with the synchrotron and dust templates to correct CMB observations for diffuse Galactic foregrounds. We have used the COBE-DMR data at 31.5, 53 and 90 GHz and employed cross-correlation techniques to...

BACKGROUND Direct myocardial revascularization (DMR) has been examined as an alternative treatment for patients with chronic refractory myocardial ischemic syndromes who are not candidates for conventional coronary revascularization. Methods and Results-We used left ventricular electromagnetic guidance in 77 patients with chronic refractory angina (56 men, mean age 61+/-11 years, ejection fract...

In dynamic object-oriented languages, low-level mechanisms such as just-in-time compilation, object allocation, garbage collection (GC) and method dispatch are o‰en handled by virtual machines (VMs). VMs are typically implemented using static languages, allowing only few changes at run time. In such systems, the VM is not part of the language and interfaces to memory management or method dispat...

BACKGROUND Matrix effects in HPLC-electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS)1 can cause differences in the ionization of an internal standard (IS) compared with the analyte of interest. Unless sample cleanup or chromatographic conditions eliminate or minimize ion suppression or enhancement, variability in interpatient matrices may cause erroneous results. A stable isotope...

Functional safety is a key requirement in several application domains which microprocessors are an essential part. A number of redundancy techniques have been developed with the common purpose protecting circuits against single event upset (SEU) faults. In microprocessors, functional may be achieved through multi-core or simultaneous-multi-threading architectures, that broadly classifiable as D...

The most frequent BCR-ABL1-p210 transcripts in chronic myeloid leukemia (CML) are e14a2 and e13a2. Imatinib (IM) is the common first-line tyrosine–kinase inhibitor (TKI) used to treat CML. Some studies suggest that BCR-ABL1 transcript types confer different responses IM. objective of this study was correlate expression or e13a2 clinical characteristics, cumulative cytogenetic molecular IM, acqu...