We sought to determine the mechanisms for hyperactivity and abnormal platelet Ca(2+) homeostasis in diabetes. The glycosylated Hb (HbA(1c)) level was used as an index of glycemic control. Human platelets were loaded with Ca- green-fura red, and cytosolic Ca(2+) ([Ca(2+)](i)) and aggregation were simultaneously measured. In the first series of experiments, the platelets from diabetic and normal ...

The mechanical properties of bone depend largely on its degree and distribution of mineralization. The present study analyzes the effect of an inhomogeneous distribution of mineralization on the stress and strain distributions in the human mandibular condyle during static clenching. A condyle was scanned with a micro-CT scanner to create a finite element model. For every voxel the degree of min...

A netrin homolog of the sea urchin, Hemicentrotus pulcherrimus (HpNetrin) was characterized in terms of its expression behavior. The predicted amino acid sequence was an ortholog of hemichordate netrin-1. Reverse transcriptase-PCR, immunoblotting, and whole mount immunohistochemistry showed that gene transcription and protein expression occurred from 15-hour post-fertilization (hpf) swimming bl...

This article was submitted to HR by Douglas L. Beck, AuD, director of professional relations at Oticon Inc, Somerset, NJ; David P. Speidel, MS, director of audiology services, and Michelle Petrak, PhD, audiologist and product manager at Interacoustics, Eden Prairie, Minn. Correspondence can be addressed to [email protected] or Douglas Beck at Oticon Inc, 29 Schoolhouse Road, Somerset, NJ...

Vinyl and p-nitrophenyl esters have emerged as alternative substrates for the LovD9 acylation mechanism, showing product yields high those obtained by α-dimethylbutyryl-S-methyl-3-mercaptopropionate (DMB-SMMP), thioester which was evolved. More information can be found in Research Article G. Jiménez-Osés, F. López-Gallego co-workers (DOI: 10.1002/chem.202300911).

BACKGROUND 3,3'-Dimethylbenzidene (DMB) is a substance classified into the group of carcinogens. The value of maximum admissible concentration for this substance in the workplace air is not specified in Poland. Bearing in mind that DMB is used in domestic companies there is a need to develop a sensitive method for determining 3,3'-dimethylbenzidine in the work environment. MATERIAL AND METHOD...