Amylin is secreted with insulin from the pancreas during and after food intake. One of the most potent actions of amylin in vivo is its anorectic effect, which is directly mediated by the area postrema (AP), a circumventricular organ lacking a functional blood-brain barrier. As we recently demonstrated, amylin also stimulates water intake most likely via its excitatory action on subfornical org...

It is known that mice injected peripherally with ANG II do not show a drinking response but that cFos immunoreactivity (ir) is induced in brain regions similar to those in rats. We now show in Crl:CD1(ICR) mice that peripheral injection of the ANG II type 1 receptor antagonist losartan was sufficient to prevent this induction of Fos-ir in the subfornical organ (SFO). Injection of ANG II into th...

La SFO est entrée dans sa quarantième année. Après une évocation des circonstances de fondation, nous mettons en évidence les caractéristiques et activités qui permettent d’affirmer que notre société a réussi à créer communauté scientifique vivante bonne interaction avec ses environnements tant géographique.

In this study, a modified salting-out-assisted liquid-liquid extraction (SALLE) combined with low density dispersive microextraction (LD-DLLME) has been developed for quantitative determination of multiclass pesticide residues (atrazine, diazinon, ametryn, terbutryn, chlorpyrifos, dimethametryn, 4,4'-dichlorodiphenyldichloroethylene (4,4'-DDE), 4,4'-dichlorodiphenyldichloroethane (4,4'-DDD) and...

The mechanism and route whereby glucagon-like peptide 1 (GLP-1) receptor agonists, such as GLP-1 and exendin-4 (Ex-4), access the central nervous system (CNS) to exert their metabolic effects have yet to be clarified. The primary objective of the present study was to investigate the potential role of two circumventricular organs (CVOs), the area postrema (AP) and the subfornical organ (SFO), in...

has been approved by the Examining Committee for the thesis requirement for the Doctor of Philosophy degree in Pharmacology at the May 2015 graduation. ii ACKNOWLEDGMENTS I would like to acknowledge my mentor, Dr. Curt Sigmund, for given the opportunity to develop myself as a scientist, and for supplying me with the appropriate guidance. I would like to acknowledge, Dr. Justin Grobe, for also g...

It has been 30 years since landmark studies by Johnson and Brody1 revealed a pivotal role for the forebrain circumventricular organs (CVOs) in experimental hypertension. We have since come to understand that these small midline structures, mounted along the cerebral ventricles and lacking well-formed blood-brain barriers, shoulder a huge responsibility for maintaining the delicate balance of ca...

Shape-from-X is an important class of problems in the fields of geometry processing, computer graphics, and vision, attempting to recover the structure of a shape from some observations. In this paper, we formulate the problem of shape-from-operator (SfO), recovering an embedding of a mesh from intrinsic differential operators defined on the mesh. Particularly interesting instances of our SfO p...

In this study aliphatic polyacids were synthesized using palm acid oil (PAO) and sunflower oil (SFO) via addition reaction technique. The synthesized materials were characterized using Fourier-transform infra-red (FTIR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF-MS) and thermo-gravimetric a...