ABSTRAK Pengawasan yaitu gerakan yang amat berguna sehingga pekerjaan dan usaha diturunkan ke aparat terlaksanan diselesaikan dengan rencana telah ditentukan. cara untuk memutuskan langkah-langkah pelaksanaan membuat dapat mendukung pencapaian hasil normal cocok presentasi ditentukan sebelumnya. Masalah kelautan perikanan adalah masalah selalu menjadi bahan pembicaraan masyarakat maupun penegak...

(1) Background: The aim of this study was to identify the degradation product ramipril (RAM) formed under dry air and verify its potential modes carcinogenicity. We intended check whether formation presence in final dosage forms could pose a cancer risk humans who are treated with RAM due cardiological indications. carcinogenicity compound evaluated respect two mechanisms: direct DNA-damage ind...

Bacteriolytic enzymes are promising antibacterial agents, but they can cause a typical immune response in vivo . In this study, we used targeted modification method for two endolysins, Pal and Cpl-1. We identified the key immunogenic amino acids, designed tested new, bacteriolytic variants with altered immunogenicity. One new variant of (257-259 MKS → TFG) demonstrated decreased immunogenicity ...

Chemical analysis of an Australian marine sediment-derived Aspergillus sp. (CMB-M081F) yielded the new diketomorpholine (DKM) shornephine A (1) together with two known and one new diketopiperazine (DKP), 15b-β-hydroxy-5-N-acetyladreemin (2), 5-N-acetyladreemin (3), and 15b-β-methoxy-5-N-acetyladreemin (4), respectively. Structure elucidation of 1-4 was achieved by detailed spectroscopic analysi...

The total descendent potential of a simple singularity satisfies the Kac–Wakimoto principal hierarchy. Bakalov and Milanov showed recently that it is also a highest weight vector for the corresponding W -algebra. This was used by Liu, Yang and Zhang to prove its uniqueness. We construct this principal hierarchy of type D in a different way, viz. as a reduction of some DKP hierarchy. This gives ...

Thirty litres of fermentation broth was extracted from the newly isolated Streptomyces sp. strain TN17 and various separation and purification steps led to the isolation of three pure bioactive compounds (1-3). Compound 1: cyclo (L-Leu-L-Arg), a diketopiperazine 'DKP' derivative; 2: di-(2-ethylhexyl) phthalate, a phthalate derivative; and 3: cyclo 1-[2-(cyclopentanecarbonyl-3-phenyl-propionyl]-...

The present invention relates to produce multiple unit particle system (MUPS) of stabilized ramipril pellets, hydrochlorothiazide, diluents, superdisintegrants, and lubricants which produce better dissolution of the system for better bioavailability with improving stability and bioavailability of ramipril. More particularly, the present invention is directed for stabilized ramipril against deco...

The design, synthesis and conformational studies of a new b-hairpin mimic, 2, are described in this paper. The design towards hairpin 2 is based on the assembly of the bifunctional DKP-1 as a b-turn inducer, a peptidomimetic strand, namely 5-amino-2-methoxybenzhydrazide, to stabilize the formation of b-sheets, and finally a tetrapeptide sequence, GVVI, containing the hydrophobic residues Val, I...