In rats, a Mg(2+)-deficient diet, which in a few days dramatically decreased the Mg(2+) concentration in plasma, cerebrospinal fluid (CSF) and spinal cord, was accompanied by a significant lowering of the nociceptive threshold. After reloading, the Mg(2+) concentration was rapidly normalized in both spinal cord and CSF. In parallel, the neurological disturbances induced by Mg(2+) deficiency van...

Chronic administration of a psychomotor stimulant has been shown to produce progressively enhanced effects, a phenomenon called "reverse tolerance" or sensitization. The present study reexamined the effects of the daily injection of phencyclidine on locomotor activity and stereotypy in rats, and investigated whether drug-environment conditioning was necessary for the development of behavioral s...

Objectives: The aim of our research is to study the effect dipentylphthalate (DPeP), a plasticizer on cognition and various oxidative stress markers in mice, explore modulatory effects MK-801. Methods: In present study, experimental mice were orally treated with two doses (33 100 mg/kg) DPeP for 28 days. Cognitive functions assessed using spatial navigation task Morris water maze (MWM) step-dow...

Here we tested in rats effects of the procognitive drugs modafinil and methylphenidate on post-acquisition performance in an object-location paired-associates learning (PAL) task. Modafinil (32; 64 mg/kg) was without effect, while higher (9 mg/kg) but not lower (4.5 mg/kg) doses of methylphenidate impaired PAL performance. Likewise, higher but not lower doses of amphetamine (0.4; 0.8 mg/kg) and...

[This corrects the article on p. 75 in vol. 9, PMID: 25883558.].

Sihver, S. 2000. Development of in vitro and ex vivo positron-emitting tracer techniques and their application to neurotrauma. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 942. 52 pp. Uppsala. ISBN 91-554-4771-6. The use of positron-emitting tracers has been extended beyond tomographic facilities in the last few years, giving rise...