Bone marrow transplantation (BMT) is currently the treatment of choice for patients with globoid cell leukodystrophy (GLD), particularly in the early phases of the disease. Elevated interleukin (IL)-6 levels in the central nervous system of the twitcher mouse, an animal model for GLD, have been held responsible for severe graft versus host disease (GVHD), and IL-6 knock-out mice have shown lowe...

We have precisely mapped and sequenced the three 5' exons of the Drosophila melanogaster Gld gene and have identified the start sites for transcription and translation. The first exon is composed of 335 nucleotides and does not contain any putative translation start codons. The second exon is separated from the first exon by 8 kb and contains the Gld translation start codon. The inferred amino ...

B cell malignancies arise with increased frequency in aging individuals and in patients with genetic or acquired immunodeficiency (e.g., AIDS) or autoimmune diseases. The mechanisms of lymphomagenesis in these individuals are poorly understood. In this report we investigated the possibility that mutations at the Fas (lpr) and Fasl (gld) loci, which prevent Fas-mediated apoptosis and cause an ea...

the aim of this paper is to project extreme precipitation events in an arid and a semiarid station. in order to project climate change based on general circulation models (gcms), we have applied lars-wg[1] downscaling tool. this stochastic weather generator down-scaled the climate of two synoptic stations using hadcm3 model and a2 emission scenario for 2040. we extracted extreme precipitation e...

Two parts, each with two holes, are to be pinned together by some type of fastener. Nominally the holes on part 1 are to match the holes on part 2 and the fastener diameters should be smaller than the hole diameters. Due to variation in hole diameters, fastener diameters and hole center positions loose pinning of the two parts may no longer be possible. The problem considered here is to define ...

Let X ⊂ PdK be Drinfeld’s upper half space over a finite extension K of Qp. We construct for every GLd+1-equivariant vector bundle F on PdK , a GLd+1(K)equivariant filtration by closed subspaces on the K-Fréchet H(X ,F). This gives rise by duality to a filtration by locally analytic GLd+1(K)-representations on the strong dual H(X ,F). The graded pieces of this filtration are locally analytic in...

Let X ⊂ PdK be Drinfeld’s upper half space over a finite extension K of Qp. We construct for every GLd+1-equivariant vector bundle F on PdK , a GLd+1(K)equivariant filtration by closed subspaces on the K-Fréchet H(X ,F). This gives rise by duality to a filtration by locally analytic GLd+1(K)-representations on the strong dual H(X ,F). The graded pieces of this filtration are locally analytic in...

The GLD-2 family of poly(A) polymerases add successive AMP monomers to the 3' end of specific RNAs, forming a poly(A) tail. Here, we identify a new group of GLD-2-related nucleotidyl transferases from Arabidopsis, Schizosaccharomyces pombe, Caenorhabditis elegans, and humans. Like GLD-2, these enzymes are template independent and add nucleotides to the 3' end of an RNA substrate. However, these...

Efficient and accurate template matching in multisource images is a difficult task when hardware platform resources are limited. Motivated by the problems encountered present methods, scheme, called Matching Pixel Distribution Comparison (MPDC), proposed to reduce use of system combining traditional algorithms neural networks. The MPDC scheme first extracts distribution information image pixels...

Abstract The oxidation of sulfide minerals in mine wastes is a possible threat to the environment as it might have potential generate acid rock drainage (ARD). A common method reduce ARD apply dry cover on waste deposit. Considering massive amounts produced Sweden (104-million-ton year 2018) there great need for suitable materials. Using non-hazardous industrial residues would be beneficial bot...