The purpose of this study was to develop a suitable dissolution test for feverfew products and to investigate the parthenolide content, disintegration, and dissolution performance of several marketed feverfew products. Parthenolide content was determined by a validated HPLC method. Disintegration was tested according to the USP requirements for botanical dosage forms. A suitable dissolution tes...

Because drug quality is the focus for pharmaceutical industry and regulatory agencies, the in vitro dissolution test becomes a standard tool for characterization of manufactured products. However, results of the dissolution test must be expressed in mathematical terms; this is realized by fitting various models to the cumulative dissolution curves. The models might be either mechanistic or empi...

BACKGROUND Since 2005, the antiepileptic drug lamotrigine has been present in the market in various generic products, in addition to the original brand of Lamictal®. The linear pharmacokinetics and wide therapeutic window of lamotrigine enable seizure-free patients to easily switch from brand to generic antiepileptic drugs. OBJECTIVE The aim of this study was to investigate the extent of vari...

Introduction Dissolution testing has increased in value and significance over the last quarter century. It has been used extensively to guide formulation development and to monitor formulation development,formulation changes, and manufacturing of products for new drugs. It is also widely used as a quality control tool to monitor the batchto-batch consistency of drug release from a product. Ther...

Previous research finds that marriage is associated with better health and lower mortality, and one of the mechanisms underlying this association is health-related selection out of marriage. Using longitudinal survey data from 2,348 couples from the Fragile Families and Child Wellbeing Study, we examine whether certain health behaviors-smoking and binge drinking-are associated with risk of unio...

Calcium polyphosphate (CPP) bioceramic with different porosities were prepared by controlling the concentration of the pore-foaming agent. Effect of porosity (0%, 15%, 30%, 45% and 60%) on the microstructure, pores interconnection, dissolution behavior and compressive strength of CPP bioceramic were investigated. Scanning electron microscope (SEM) and capillarity test results indicated that CPP...

Although constant progress in pacing lead design and life time of pacemaker battery has contributed to the clinical success of this treatment option, the mechanism of drug release from steroid-eluting pacing leads is not completely understood. Besides, drug concentrations of steroids released into the heart-tissue remain unclear. Therefore, three different dissolution test methods were examined...

The aim of this study was to develop a novel microbially triggered and animal-sparing dissolution method for testing of nanorough polysaccharide-based micron granules for colonic drug delivery. In this method, probiotic cultures of bacteria present in the colonic region were prepared and added to the dissolution media and compared with the performance of conventional dissolution methodologies (...

OBJECTIVES To determine the organic matter dissolution and changes in dentin chemical composition promoted by different concentrations of NaOCl over time. MATERIAL AND METHODS Fragments of bovine muscle tissue were weighed before and after 5, 10, and 15 min of immersion in the groups (n=10): G1- 0.9% saline solution; G2- 1% NaOCl; G3- 2.5% NaOCl; and G4- 5% NaOCl. Bovine dentin fragments were...