To investigate the function of trichohyalin during terminal differentiation of the skin, immunohistochemical studies were performed on trichohyalin and its related proteins, filaggrin and involucrin, the components of the cornified cell envelope. In skin disorders unrelated to tumours, weak trichohyalin expression was found in a few granular cells or in the horny layer of psoriasis, ichthyosis,...

Porokeratosis ptychotropica is a rare variant of porokeratosis that is classically located on the gluteal and perianal regions, seldom extending to the genitalia. The authors report an atypical presentation of porokeratosis ptychotropica and discuss the use of dermoscopy in evaluating this dermatosis. Dermoscopic findings, although not specific to this variant of porokeratosis, are helpful in t...

Porokeratosis is a specific disorder of keratinization that has five major clinical types and shows a characteristic cornoid lamella on histopathology. Giant porokeratosis is considered to be a morphological variant of porokeratosis of mibelli. Malignant degeneration has been described in all forms of porokeratosis but highest risk is associated with linear and giant porokeratosis . We report a...

Porokeratosis is characterized clinically by annular plaques with a distinct peripheral keratotic ridge and histologically by the cornoid lamella. Porokeratosis with follicular involvement is rarely reported. To provide the basis of that follicular porokeratosis is a clinical variant or not. Biopsy was taken from three patients who were diagnosed porokeratosis. Routine stain was made and review...

Porokeratosis is a specific disorder of keratinization that has five clinical types and shows a characteristic 'cornoid lamella' on histopathology. Malignant degeneration has been described in all forms of porokeratosis. To the best of our knowledge, this is the first Indian report of multicentric squamous cell carcinoma complicating porokeratosis.

Porokeratosis of Mibelli is a disorder of epidermal proliferation in which many different clinical forms can be distinguished. Two male patients with a localized type of porokeratosis limited to the genitalia are reported. Later in life they developed an annular skin lesion with peripheral keratotic ridge. The histological examination of a biopsy specimen showed the characteristic features of p...

Observations: Porokeratosis is a dyskeratotic disorder of the skin characterized by hyperkeratotic papule or plaque with an annular appearance and usually diagnosed easily, both histopathologically and clinically. We present a case of linear porokeratosis which was most likely suggesting the linear epidermal nevus and linear lichen planus. We observed a tiny brown border in the dermoscopic exam...

© 2012 The Authors. doi: 10.2340/00015555-1166 Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Imiquimod (AldaraTM, 3M Pharmaceuticals) is a member of the imidazoquinolone family of drugs. It is a topical treatment approved by the US Food and Drug Administration (FDA) for the treatment of external genital and perianal warts, non-hypertrophic actinic keratoses in immunocomp...