Aims With novel promising therapies potentially limiting progression of Dupuytren’s disease (DD), better patient stratification is needed. We aimed to quantify DD development and after seven years in a population-based cohort, identify factors predictive or progression. Methods All surviving participants from our previous prevalence study were invited participate the current prospective cohort ...

Abstract Background Many factors may play a role in the severity and progression of gastroesophageal reflux disease (GERD) since pathophysiology is multifactorial. Data regarding GERD are controversial: some reports increased esophageal acid exposure (EAE) mucosal damage were considered as evidence for stable course, while others interprete these findings progression. The aim this study to anal...

Several studies provide compelling support for the use of MRI as a sensitive non-invasive method to assess skeletal muscle disease progression in various neuromuscular diseases, including Duchenne muscular dystrophy1,2 and limb girdle muscular dystrophy type 2I.3 In The Lancet Neurology, Jasper Morrow and colleagues4 now report the sensitivity of MRI to track disease progression in 20 patients ...

neurodegenerative disease are characterized by the progressive loss of neurons from specific origins of the cns .alzheimer disease (ad) is a neurodegenerative disorder which affect brain regains that control memory and ability to learn. it is estimated that 27 million people are affected word wide and this number is expected to triple by 2050 due to increase of the population life expectancy. a...

impaired fasting glucose identifies individuals at high risk of progression to diabetes but the role of ifg as a coronary artery disease risk factor, independent of its progression to diabetes and its association with other coronary artery disease risk factors ,is unclear. a cross-sectional study was conducted to evaluate the hypothesis that impaired fasting glucose increased the likelihood of ...

objective: chronic periodontitis is the most common form of periodontal disease. changes in biomarkers seem to be associated with the disease progression. procalcitonin (pct) is one of these biomarkers that are altered during infection. this study was established to investigate the relationship between periodontitis as an infectious disease and salivary pct. materials and methods: this case-con...

background: diabetic nephropathy is considered to be the most common cause of end stage renal disease (esrd). proteinuria is declared as the most marked risk factor in progression towards esrd. the aim of this study was to evaluate the efficacy of pentoxifylline for reduction of proteinuria in type ii diabetic patients. methods: from may 2007 to june 2008, this randomized clinical trial study w...

dream should be considered as a kind of cognitive ability that is formed parallel to other cognitive capabilities like language. on the other hand, multiple sclerosis (ms) is a complex disease that can involve different aspects of our cognition. therefore, ms may influence patients' dreams. in fact, we do not know what the importance of dream is in ms, but further studies may introduce dream an...

fecal microbiota transplant (fmt) research trials are growing in diverse intestinal and extraintestinal conditions that are thought to be either caused or correlated with gut microbiota dysbiosis. although, the mechanism by which the microbiota results in disease initiation or progression is not fully understood, it is speculated that restoring the symbiosis by fmt could have therapeutic benefits.