For many years scientists have examined the possible existence of extra-sensory perception (ESP). One of the most common types of experiment, referred to as a ‘forced choice’ study, involves participants attempting to guess the identity of hidden targets that have been randomly selected from a set of alternatives known to participants prior to making their guess. Many researchers have argued th...

OBJECTIVE To analyze scopes and limits of the use of participatory methodology of evaluation with municipal health managers and administrators. METHODS Qualitative research with health policymakers and managers of the Comissão Intergestores Regional (CIR - Regional Interagency Commission) of a health region of the state of Sao Paulo in Brazil. Representatives from seven member cities particip...

As part of a population based study of Prader-Willi syndrome (PWS), we have examined more closely the relationship between clinical and genetic diagnoses in a large number of people with established or suspected PWS. We report here on agreements and disagreements between clinical and genetic diagnoses. We consider whether a genetic diagnosis implies the presence of any one (or more) of the majo...

The Quest for Cortisone chronicles the pursuit and successful isolation, synthesis, and clinical use of cortisone. The author, Thom W. Rooke, is a graduate of Johns Hopkins School of Medicine. He completed internal medicine and cardiovascular medicine residencies at the Mayo Clinic, following which, he joined Mayo’s vascular medicine section. Rooke is now Professor of Vascular Medicine at Mayo....

In January 1949, 9-year-old Betty stepped through the doors of the Cincinnati Child Guidance Home. For the next 2 years, the Home would attempt to treat her severe emotional and behavioral problems in an experimental approach called residential treatment. After 4 years of child welfare and child guidance interventions, the Home was a last resort. Betty’s home life was a mess. When she was 3, he...

Chromosomal 15q11-q13 region is of great interest in Human Genetics because many structural rearrangements have been described for it (deletions, duplications and translocations) leading to phenotypes resulting in conditions such as the Prader-Willi (PWS) and Angelman (AS) syndromes which were the first human diseases found to be related to the differential expression of parental alleles (genom...

Katherine Hayles’s How We Became Posthuman matches its rhetoric to its argument by highlighting anxiety in its cybernetic subjects as we face the prospect of disembodied humanity. Medievalists should be sympathetic since embodiment is key to the conception of full medieval personhood. Hayles reacted against a new desire to loosen the link of person to body and much speculative thinking continue...

Despite forays into editing, consulting, and teaching, I still consider myself first and foremost a clinician. And, at that, I like to think of myself as an evidence-based clinician. For me this appreciation of the importance of research in my day-to-day clinical decision-making did not come easy. My entry-level degree in physical therapy strongly emphasized authority-based knowledge and clinic...

This is based on experience and contacts with numerous science educators who have been concerned with “HAVE NOT” (less advantaged/disadvantaged/socially, culturally, and economically different) students around the world. I conclude that recent curricular efforts in science and technology education offer no solutions for these students. The failure is partly due to the structure of the present s...

CASE “Maria is stubborn, willful and always full of energy. For the past 2 months, I [haven’t been able to] leave her for a moment without her grabbing me and crying. She refuses to sit on the potty seat. Yesterday, she threw herself on the floor, yelling and kicking after I suggested she use the potty seat. Tantrums occur every day—sometimes in response to a simple request.” Maria’s mother off...