BACKGROUND The aim of present study was to develop the novel methods for chemical and physical modification of superparamagnetic iron oxide nanoparticles (SPIONs) with polymers via covalent bonding entrapment. These modified SPIONs were used for encapsulation of anticancer drug doxorubicin. METHOD At first approach silane-grafted magnetic nanoparticles was prepared and used as a template for ...

Ladder polyether natural products are a class of natural products denoted by their high functional-group density and large number of well-defined stereocenters. They comprise the toxic component of harmful algal blooms (HABs), having significant negative economic and environmental ramifications. However, their mode of action, namely blocking various cellular ion channels, also denotes their pro...

Copper complexes obtained from the reactions between 2-thiouracil and cupric hydroxide in different solvents have been investigated. Mononuclear or polynuclear complexes of Cu(I) have been obtained depending on the reaction conditions. Hydroxo complexes of copper(I) have been obtained at pH around 3.5. 2-Thiouracil acts as monoor bidentate ligand in complexes. [Cu(H2TU)2 OH], [Cu5(H2TU)6 (OH)5]...

Four simple, rapid and sensitive spectrophotometric methods have been proposed for the determination of enalapril maleate in pharmaceutical formulations. The first method is based on the reaction of carboxylic acid group of enalapril maleate with a mixture of potassium iodate (KIO(3)) and iodide (KI) to form yellow colored product in aqueous medium at 25 +/- 1 degrees C. The reaction is followe...

1. Bile salts of Petromyzon marinus L. ammocoetes appeared to consist solely or chiefly of a crystalline substance, whose chromatographic and i.r.-spectral characteristics suggested that it was a monosulphate ester of a bile alcohol having the 3alpha,7alpha,12alpha-trihydroxy pattern of substitution in a 5alpha-steroid nucleus. 2. This substance on cleavage with dioxan-trichloroacetic acid gave...

7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD chloride) and 7-(2'-hydroxyethylthio)-NBD (obtained from NBD chloride and mercaptoethanol) undergo a reversible spectral change in alkaline solution that depends respectively on a single apparent pK(a) 9.76 (at 25 degrees C) and 8.81 (at 32 degrees C). In acid solution however no spectral change was observed. NBD chloride reacts slowly with papain at...

Background: Winged bean (Psophocarpus tetragonolobus (L.) D.C.), is unique legume which has numerous phytochemical with distinct properties. So, this research work was performed to explore and quantify the bioactive compound from different extracts of winged seeds through GC-MS assess bio-efficacy on cowpea seed protect them against deterioration bruchid. Methods: The compounds (from solvents, ...