The rising threat of Plasmodium falciparum resistance to Monotherapies has prompted the world health organization (WHO) 2006 guidelines recommend use different anti-malarias. In this study, anti-malaria and hypoglycaemic activities Diosgenin, a potent, yet poorly reported saponin was investigated on P. inoculated Alloxan-Induced, Diabetic Wistar Rats. Fort two (42) adult male wistar rats betwee...

A plant-based straightforward and short four-step synthesis of cholesterol starting from commercially available diosgenin is reported. This offers a large-scale production highly needed GMP-grade cholesterol, which part the lipid cocktail for assembly effective mRNA-based vaccines against COVID-19 pandemic. These lipids are formulated into delivery system mRNA fragments by forming Lipid Nano Pa...

Geeldikkop was induced in a sheep by dosing it orally with a crude extract of the steroidal saponins from Tribulus terrestris. GC-MS analysis of the sheep's ruminal contents, bile, faeces and urine for free and conjugated sapogenins, revealed the general features of the metabolic pathway by which diosgenin and yamogenin glycosides were converted into the glucuronides of epismilagenin and episar...

S. securidaca seeds are reported to treat a variety of diseases; they contain multiple antidiabetic constituents and widely used as anti-hyperglycemic, antibacterial, well anti-hyperlipidemic agents. The present work aimed propose tablet formulations containing extracts in an attempt obtain antibacterial anti-hyperglycemic with more efficient oral hypoglycemic impact, limited side effects, high...