Abstract Study question To determine whether hypoxic ovarian damage is due to increased growth and follicles “burnout” or apoptosis, this age dependent. Summary answer Direct tissue hypoxia causes activation recruitment of dormant without apoptotic changes. This effect dependent, more pronounced in adult- versus newborn ovaries. What known already In a previous study we have shown that perinata...

The ovary receives a finite pool of follicles during fetal life. Atresia remains the major form of follicular expenditure at all stages since development of ovary. The follicular reserve, however, declines at an exponential rate leading to accelerated rate of decay during the years preceding menopause. We examined if diminished follicle reserve that characterizes ovarian aging impacts the attri...

Background Reduced ovarian reserve has been known to predict poor ovarian response and poor success rates in infertile women undergoing assisted reproductive technology. Ovarian reserve also decreases with age but the rate of decline defers from a woman to another. The aim of this study was to detect any difference in ovarian reserve as measured by basal serum FSH and AMH between matched cohort...