condensation of aromatic aldehydes with benzoyl acetone under specified conditions yieldedtwo series of polycarbonyl compounds in which the keto group is attached to olefinic linkage.spectral and analytical data revealed the formation of an unsaturated triketone from pyridine-3-carbaldehyde and unsaturated diketone from furfural, salicylaldehyde and 2-hydroxynaphthaldehyde. analytical, ir, 1h n...

Aldose reductase (ALR2) inhibition is the most legitimate approach for the management of diabetic complications. The limited triumph in the drug development against ALR2 is mainly because of its close structural similarity with the other members of aldo-keto reductase (AKR) superfamily viz. ALR1, AKR1B10; and lipophilicity problem i.e. poor diffusion of synthetic aldose reductase inhibitors (AR...

Aldolase antibodies that operate via an enamine mechanism were developed by in vitro selection. Antibody Fab phage display libraries were created where the catalytic active site residues of aldolase antibodies 38C2 and 33F12 were combined with a naive human antibody V gene repertoire. Selection from these libraries with 1,3-diketones covalently trapped the amino groups of reactive lysine residu...

A series of enolic Schiff base aluminum(III) complexes LAlR (where L=NNOO-tetradentate enolic Schiff base ligand) containing ligands that differ in their steric and electronic properties were synthesized. Their single crystals showed that these complexes are five-coordinated around the aluminum center. Their coordination geometries are between square pyramidal and trigonal bipyramidal. Their ca...

We employ transient absorption from the deep-UV to the visible region and fluorescence upconversion to investigate the photoinduced excited-state intramolecular proton-transfer dynamics in a biologically relevant drug molecule, 2-acetylindan-1,3-dione. The molecule is a ß-diketone which in the electronic ground state exists as exocyclic enol with an intramolecular H-bond. Upon electronic excita...

Treatment of a sulfide with catalytic amount 1,3-diketone in the presence silica sulfuric acid as co-catalyst and hydrogen peroxide (50% aq) stoichiometric oxidant leads to corresponding sulfoxide product. The reaction is effective for diaryl, aryl-alkyl dialkyl sulfides tolerant oxidisable sensitive functional groups. Investigations have shown that tris-peroxide 2, formed on pentane-2,4-dione ...