نتایج جستجو برای: dihydro 2 oxypyrrole derivatives

تعداد نتایج: 2605389  

Journal: :Molecules 2005
Bahittin Kahveci

Iminoester hydrochlorides 1 have been synthesized. These compounds were then converted into ester ethoxycarbonyl hydrazones 2, from which in turn a new series of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones, 3, was then prepared. Finally a set of isatin imine derivatives 4 was obtained from the reaction of compounds 3 with isatin. The structures of all the new synthesized compounds ...

2013
Barbara Czochralska

The electrochemical reduction of 2-oxopurine in buffered aqueous medium was found to proceed via two successive one-electron additions. The initial one-electron step involves the addition of a proton, leading to formation of a free radical which rapidly dimerizes. At more negative potentials, reduction leads to formation of l,6-dihydro-2-oxopurine. The product of reduction on wave I was isolate...

Journal: :The Journal of pharmacology and experimental therapeutics 2001
S Singh C A Syme A K Singh D C Devor R J Bridges

The diseases of cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are characterized by mucus-congested airways. Agents that stimulate the secretion of Cl- are anticipated to facilitate mucociliary clearance and thus be of benefit in the treatment of CF and COPD. Recently 1-EBIO (1-ethyl-2-benzimidazolinone or 1-ethyl-1,3-dihydro-2H-benzimidazol-2-one) was shown to stimulate ...

2013
Dmytro Atamanyuk Borys Zimenkovsky Vasyl Atamanyuk Ihor Nektegayev Roman Lesyk

Novel 11-substituted 3,11-dihydro-2H-benzo[6,7]thiochromeno[2,3-d][1,3]-thiazole-2,5,10-triones 4a-i were synthesized in 75-90% yields via the hetero-Diels-Alder reaction of 5-arylidene-4-thioxo-2-thiazolidinones with 1,4-naphthoquinone. The synthesized compounds were evaluated for their antineoplastic and antimycobacterial activities. A moderate selectivity against melanoma cancer cells (GI50 ...

Journal: :Organic letters 2002
Yu Yuan Xin Li Kuiling Ding

[reaction: see text] A highly efficient aza Diels-Alder reaction of Danishefsky's diene with imines was found to occur in methanol in the absence of any acids at room temperature to give corresponding 2-substituted dihydro-4-pyridone derivatives in high yields. This reaction can be also carried out in a three-component one-pot reaction manner. The reaction was found to proceed through a Mannich...

Journal: :International Journal of Biological and Chemical Sciences 2022

An undescribed phyllocoumarin-3-O-α-L-rhamnopyranoside 8 together with catechin 1, catechin-3-O-α-L-rhamnopyranoside 2, catechin-[7,8-bc]-4β-(3,4-dihydroxyphenyl)-dihydro-2(3H)-pyranon 3, 5-O-trans-p-coumaroylquinic acid 4, trans-p-coumaric 5, catechin-[5,6-e]-4β-(3,4-dihydroxyphenyl)-dihydro-2(3H)-pyranon 6, catechin-[5,6-e]-4α-(3,4-dihydroxyphenyl)-dihydro-2(3H)- pyranon 7, phyllocoumarin 9 a...

Journal: :Archiv der Pharmazie 2003
Sahar Mahmoud Tarek Aboul-Fadl Mahmoud Sheha Hassan Farag Abdel-Maaboud I Mouhamed

In order to overcome the slow oxidation of 1, 2-dihydro-N-alkylisoquinoline, 1, 2-dihydroisoquinoline-N-acetic acid derivatives (3b-d) were designed and synthesized as new chemical delivery systems (CDS) for the brain. Molecular orbital calculations for the suggested derivatives revealed that these carriers are stable against oxidation. However, hydrolysis to their corresponding anions will acc...

One of the most important goals in medicinal chemistry is the development of new techniques and new heterocyclic compounds with pharmaceutical activity. The present study aimed to use a method for the synthesis of some 1,2-Dihydro-1-arylnaphtho [1,2-e] [1,3] oxazine-3-ones. The question this study tried to answer was this reaction can be performed in present of nano-Fe2O3 as an acid catalyst an...

2-Amino-5,10-dioxo-4-aryl-5,10-dihydro-4H-benzo[g]chromene-3-carbonitrile derivatives are obtained in excellent yields with a simple and efficient procedure.This reaction can occur using electrocatalytic multicomponent chain transformation of aryl aldehydes, 2-hydroxynaphthalene-1,4-dione and malononitrile under neutral and mild conditions. Moreover, electrolysis is done in CH3CN as solvent, Te...

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