PURPOSE To evaluate the effect of sildenafil, administered prior to renal ischemia/reperfusion (I/R), by scintigraphy and histopathological evaluation in rats. METHODS Twenty-four rats were divided randomly into two groups. They received 0.1 ml of 99mTechnetium-etilenodicisteine intravenous, and a baseline (initial) renal scintigraphy was performed. The rats underwent 60 minutes of ischemia b...

Macrophages are a heterogeneous cell type implicated in injury, repair, and fibrosis after AKI, but the macrophage population associated with each phase is unclear. In this study, we used a renal bilateral ischemia-reperfusion injury mouse model to identify unique monocyte/macrophage populations by differential expression of Ly6C in CD11b(+) cells and to define the function of these cells in th...

BACKGROUND Peritoneal dialysis is associated with changes in membrane function that can lead eventually to ultrafiltration (UF) failure. Factors driving these changes are thought to include hypertonic glucose exposure, but previously reported associations are confounded by the presence of residual renal function. METHODS Longitudinal membrane function (solute transport and UF capacity) were m...

this article is devoted to the study of existence and multiplicity of positive solutions to aclass of nonlinear fractional order multi-point boundary value problems of the type−dq0+u(t) = f(t, u(t)), 1 < q ≤ 2, 0 < t < 1,u(0) = 0, u(1) =m−2∑ i=1δiu(ηi),where dq0+ represents standard riemann-liouville fractional derivative, δi, ηi ∈ (0, 1) withm−2∑i=1δiηi q−1 < 1, and f : [0, 1] × [0, ∞) → [0, ∞...

We report a case of a 51-year-old Caucasian man referred at our department due to acute renal failure (ARF) complicating respiratory failure during hospitalization in a regional hospital. The patient was previously started on steroids due to the suspicion of rapidly progressive glomerulonephritis (RPGN) in the context of Goodpasture syndrome. However, clinical and laboratory findings did not su...