The pharmacokinetics of the C110 anti-carcinoembryonic antigen antibody radiolabeled with 111In via a novel benzylisothiocyanate derivative of diethylenetriamine pentaacetic acid have been determined in 12 patients. The chelator was attached to the protein via a thiourea bond and in such a way that all 5 carboxymethyl arms were presumably able to participate in chelation. Patients with known or...

The pharmacokinetics of the Cl 10 anti-carcinoembryonic antigen an tibody radiolabeled with '"In via a novel benzylisothiocyanate derivative of diethylenetriamine pentaacetic acid have been determined in 12 pa tients. The chelator was attached to the protein via a thiourea bond and in such a way that all 5 carboxymethyl arms were presumably able to participate in chelation. Patients with known ...

Acute disruption of blood-brain barrier (BBB) is well recognized after radiation therapy to the central nervous system (CNS). We assessed the genetic regulation of acute BBB disruption and its relationship to vascular endothelial cell death in the CNS after irradiation. Adult rats were given graded single doses of X-ray to the cervical spinal cord. At different time intervals after irradiation,...

The features of the process chemical modification polyaminoamides based on adipic acid and diethylenetriamine with rosin-maleic adducts differing in content maleopimaric (8.55; 16.46 31.12 % wt.) are considered. Modification amount equal to number secondary amino groups repeating unit polymer was carried out melt at temperature 160–180 °C for 3 h under continuous stirring. controlled by monitor...

Two polymers were prepared from diglycidyl ether of bisphenol A (DGEBA) and triglycidyl p-aminophenol (TGAP) epoxy resins, using the same hardener diethylenetriamine (DETA). The obtained compared in terms structural, optical, mechanical, thermal dielectric properties. Dielectric spectroscopy dynamic mechanical analysis indicated presence dipolar relaxations both polymers, interfacial one only f...

Interest in polynuclear complexes of the 3d metals has been stimulated by the search for new magnetic materials[1, 2] and by demonstration of the occurrence of oligonuclear metal centers in proteins such as urease.[3] Of the relatively small number of reported tetranuclear complexes of S 1 nickel( ) of known structure, the majority have a hemicubaneor TMbutterfly-∫ rather than a squarelike core...