The aim of the present study was to investigate the hepatotoxic effects of accidental intravenous diethylene glycol (DEG) poisoning in patients with liver disease. Clinical manifestations were recorded and liver function tests were carried out for 64 patients with liver disease who had been accidentally treated intravenously with DEG. Comparisons were made between the poisoned and non-poisoned ...

Results Analytical results are shown below. Figure 1 shows, from the top, the TIC data of ethylene glycol, diethylene glycol, and triethylene glycol. The commercial reagents were analyzed without modification. The results showed impurities in each sample. Since the reagents were purchased a few years ago, the impurities detected were divided into two types: original components and decomposition...

The effects of ethylene glycol monoethyl ether (EGEE) on testicular cell populations in rats were investigated by a flow cytometric method. Rats were administered by gavage with EGEE at the various doses of 0 (saline alone), 100, 200, 400, and 800 mg/kg body weight/day for 4 weeks. The treatment of EGEE caused decreases in the weight of testis and epididymis and in the number of testicular cell...

Ethylene glycol monoethyl ether (EGEE) is known to have testicular toxicity. To elucidate whether EGEE has any effect on sperm motion, especially in the case of short time exposure, we conducted a series of in vivo experiments with rats, as well as an in vitro study with rat sperm. Sperm from cauda epididymides and spermaducts was analyzed for the change in motion with a Hamilton-Thorne Sperm a...

The subchronic inhalation toxicology of ethylene glycol monoethyl ether (EGEE) was evaluated in rats and rabbits using a 13-week exposure regimen. Groups of 20 rabbits (10 M, 10 F) and 30 rats (15 M, 15 F) were exposed to a vapor of 25 ppm, 100 ppm, or 400 ppm, 6 hr/day, 5 days/week. The control groups received air only. Physical examinations and body weight measurements were conducted on all a...

Abstract The nanofrictional behavior of non-halogentated phosphonium-based ionic liquids (ILs) mixed with diethylene glycol dibutyl ether in the molar ratios 1:10 and 1:70 was investigated on titanium (Ti) substrate using atomic force microscopy (AFM). A significant reduction is observed friction coefficient μ for IL-oil mixtures a higher IL concentration (1:10, ∼ 0.05), compared to that lower ...

In summary, the case studies exploring global product supply chains and diethylene glycol poisoning in Panama, clinical trials regulation through AVAREF, premarket assurance through PEPFAR tentative approval, post-market surveillance in sub-Saharan Africa through research on drug and vaccine safety systems, and regulatory science through the creation of a low-cost meningitis vaccine for low- an...

Cloud points (CPs) of heptaoxyethylene dodecyl ether (C12E7) in the presence of varying concentrations of additives such as inorganic salts, alkanols, diols, glycols and their ethers, hydroptopes and short chain tetraalkylammonium salts are measured and the increase/decrease in CP is discussed. While inorganic anions decrease the CP due to the “salting out” (dehydration) effect and follow the H...