Dear Editor, We have examined attentively the latest manuscript by Yeganeh Mogadam et al. entitled " Comparison of Analgesic Effect between Gabapentin and Diclofenac on Post-Operative Pain in Patients Undergoing Tonsillectomy " available in Archives of Trauma Research (1). Ninety patients were included to receive 20 mg/kg oral gabapentin (n = 30), 1.0 mg/kg rectal diclofenac (n = 30) or placebo...

. Indonesia is a country with an abundance of potential natural resources. Herbaceous plants, which are found in forests and smaller than trees or shrubs, have moist stems, not woody, one type plant utilized traditional medicine. Katuk herbaceous that belongs to the Euphorbiaceae family. This study aims examine analgesic effectiveness katuk herb (Sauropus androgynus) mice (Mus musculus) compare...

The liposomal cream formulation of diclofenac, an NSAID, is an effective, safe, and convenient way to treat localized areas of inflammation in horses. The results of this study reveal urinary and serum concentrations of diclofenac following topical administration of 1% liposomal diclofenac cream for 10 days at the labeled dose and at 2X and 4X the labeled dose. These results demonstrate the slo...

Diclofenac sodium or Sodium-2-[(2, 6-dichlorophenyl) amino] phenyl] acetate, is widely used as non-steroidal antiinflammatory agent in therapeutics, it inhibits the cyclooxygenase enzyme1. Various spectrophotometric2-11, chromatographic12-18, colorimetric19-20 and flourimetric21-23 methods have been developed for quantification of diclofenac sodium. Extensive literature survey revealed that a v...

Diclofenac is a non-steroidal anti-inflammatory drug that is prescribed for treatment of rheumatic diseases and as an analgesic. Although the information about these side effects has been widely reported, little is know about the effect of diclofenac on the neural cells. In this study, we investigated the effects of diclofenac on the proliferation and differentiation of PC12 cells. The cell pro...

The pharmaceutical drug diclofenac (2-[(2,6-dichlorophenyl)amino]benzeneacetic acid) was detected in rivers and lakes in Switzerland. The data strongly suggest inputs of diclofenac from human medical use via wastewater treatment plants. Interestingly, the concentrations in a major tributary to a lake (Greifensee) were significantly higher (up to 370 ng/L) than those in the outflow of this lake ...

PURPOSE There are evidences that glibenclamide, a sulfonylurea antidiabetic agent, reduces the analgesic action of non-steroidal antiinflammatory drugs (NSAIDs), opioids and neuromodulators in animal models. The purpose of this work was to examine in the rat if such interaction involves pharmacokinetic mechanisms or is solely limited to the pharmacodynamic level. METHODS All studies were carr...

Given their established analgesic properties, nonsteroidal anti-inflammatory drugs (NSAIDs) represent an important postoperative pain management option. This study investigated: (1) the effects of mild or moderate renal insufficiency and mild hepatic impairment on the pharmacokinetics (PK) of diclofenac and hydroxypropyl-β-cyclodextrin (HPβCD) following administration of the injectable NSAID HP...

BACKGROUND Fever is the most common complaint in pediatric medicine and its treatment is recommended in some situations. Paracetamol is the most common antipyretic drug, which has serious side effects such as toxicity along with its positive effects. Diclofenac is one of the strongest non-steroidal anti-inflammatory (NSAID) drugs, which has received little attention as an antipyretic drug. OB...

Nonsteroidal anti-inflammatory drugs are frequently prescribed drug group in human and veterinary medicine. However, diclofenac, a traditional nonsteroidal anti-inflammatory drug, related to cardiotoxicity is reported, and blood cardiac damage markers may increase within the first hours after damage. The aim of the current research was to determine the effect of diclofenac on the blood cardiac ...