Rationale. The goal of antihypertensive treatment is to reduce risk of cardiovascular morbidity and mortality. Apart from blood pressure lowering per se, also reducing the activities of the renin-angiotensin system and sympathetic nervous system appears to be important. Angiotensin II receptor blocker drugs (ARBs) have provided a useful class of anti-hypertensive drugs. Eprosartan is a relative...

Driven by an interest in the impact of para-substituent calix[4]arenes on metal complexation and structural chemistry, studies p-cyclohexylcalix[4]arene (L) have been carried out. The 1:1 dichloromethane dimethylformamide solvates were found to be isostructural, different typical bilayer structure often observed for p-t-butylcalix[4]arene solvates. methanol solvate, contrast, does form a bilaye...

Magnetic nanoparticle-supported sulfanilic acid (MNPs-PhSO3H) has been used as an efficient catalyst for the preparation of 1,4-diazepines containing tetrazole ring. The catalyst has been characterized by FT-IR (Fourier-transform infrared spectroscopy), SEM (scanning electron microscope), XRD (X-ray diffraction) and VSM (vibrating-sample magnetometer). The present synthetic protocol provides se...

An efficient method for the preparation of 5-substituted 1H-tetrazole derivatives is reported using MoO3-SiO2 as an efficient heterogeneous catalyst. This method has the advantages of high yields, simple methodology and easy work-up. This catalyst could be recycled very easily, which makes this methodology environmentally benign.

[reaction: see text] Organocatalytic asymmetric Mannich reaction of protected amino ketones with imines in the presence of an L-proline-derived tetrazole catalyst afforded diamines with excellent yields and enantioselectivities of up to 99%. The amino ketone protecting group controlled the regioselectivity of the reaction providing access to chiral 1,2-diamines from azido ketones and 1,4-diamin...

The title compound, C(9)H(7)N(5), was synthesized by reaction of 4-(bromomethyl)benzonitrile and 2H-tetrazole in the presence of KOH. The relative orientation of the planar tetra-zole ring and the methyl-benzonitrile moiety is (-)-anti-clinal. The crystal packing is dominated by van der Waals inter-actions.