The need for high-concentration formulations for subcutaneous delivery of therapeutic monoclonal antibodies (mAbs) can present manufacturability challenges for the final ultrafiltration/diafiltration (UF/DF) step. Viscosity levels and the propensity to aggregate are key considerations for high-concentration formulations. This work presents novel frameworks for deriving a set of manufacturabilit...

The clinical utility of cross-linked tetrameric hemoglobin solutions is limited by peripheral vasoconstriction thought to be due to scavenging of nitric oxide. In addition, transfusion of crude preparations of hemoglobin polymers can cause arterial hypertension. We tested the hypothesis that eliminating low-molecular-weight components from the polymer solution would prevent extravasation and it...

In dairy industry there has always been great concern about the microbial and protein quality of liquid milk fractions obtained by microfiltration (MF). The objectives research were to study impact MF on evolution microfiltered (MFM), micellar casein concentrates (LMCC) serum permeates (SP) during storage at 4 °C. This was carried out with three different batches using diafiltration. Samples ch...

Antivenoms have been used successfully for more than a century and up to now constitute the only effective treatment for snakebites .The production of antivenin started long time ago when the calmette was prepared the antivenom in 1894.The method currently used to prepare antivenom by most of the manufacturers are originated from the method of Pope which was develop in 1938. Several new approac...

Plant proteins, after extraction from sources such as pea can be used functional ingredients in emulsions and gels. However, the protein fractionation route affects functionality. We investigated differences rheological properties of emulsion-filled gel (EFGs) structured by isolate obtained using either isoelectric precipitation (PPIp) or diafiltration (PPId), at varying pH oil content. PPIp PP...

28 The objective of this prospective pharmacokinetic study was to describe the variability of 29 gentamicin plasma concentrations in critically ill patients with AKI necessitating extended30 daily-diafiltration (EDD-f) using a population pharmacokinetic model and to subsequently 31 perform Monte Carlo dosing simulations to determine which dose regimen achieves 32 pharmacodynamic targets most co...

antivenoms have been used successfully for more than a century and up to now constitute the only effective treatment for snakebites .the production of antivenin started long time ago when the calmette was prepared the antivenom in 1894.the method currently used to prepare antivenom by most of the manufacturers are originated from the method of pope which was develop in 1938. several new appr...