نتایج جستجو برای: diabetic wound

تعداد نتایج: 178367  

2016
Ana Tellechea Ermelindo C. Leal Antonios Kafanas Michael E. Auster Sarada Kuchibhotla Yana Ostrovsky Francesco Tecilazich Dimitrios Baltzis Yongjun Zheng Eugénia Carvalho Janice M. Zabolotny Zuyi Weng Anastasia Petra Arti Patel Smaro Panagiotidou Leena Pradhan-Nabzdyk Theoharis C. Theoharides Aristidis Veves

Diabetic foot ulceration is a severe complication of diabetes that lacks effective treatment. Mast cells (MCs) contribute to wound healing, but their role in diabetes skin complications is poorly understood. Here we show that the number of degranulated MCs is increased in unwounded forearm and foot skin of patients with diabetes and in unwounded dorsal skin of diabetic mice (P < 0.05). Converse...

Journal: :Diabetes 2015
Weiwei Qi Chuan Yang Zhiyu Dai Di Che Juan Feng Yuling Mao Rui Cheng Zhongxiao Wang Xuemin He Ti Zhou Xiaoqiong Gu Li Yan Xia Yang Jian-Xing Ma Guoquan Gao

Diabetic foot ulcer (DFU) caused by impaired wound healing is a common vascular complication of diabetes. The current study revealed that plasma levels of pigment epithelium-derived factor (PEDF) were elevated in type 2 diabetic patients with DFU and in db/db mice. To test whether elevated PEDF levels contribute to skin wound-healing delay in diabetes, endogenous PEDF was neutralized with an an...

Journal: :Journal of Advances in Medical and Biomedical Research 2021

Synergistic Effects of Graphene Oxide and Vascular Endothelial Growth Factor Immobilized in Polycaprolactone Nanofiber as a Candidate for Diabetic Wound Healing

Journal: :Pakistan Journal of Medical and Health Sciences 2021

Background: The wound dressings perform a crucial role in cutaneous wounds management due to their ability protect and promote dermal epidermal tissue regeneration. Aim: the aim was evaluate effectiveness of using hydrogel/nano silver-based dressing vs. traditional on diabetic foot healing. Methods: Sixty patients with type-2 diabetes hospitalized for treatment were recruited from selected Surg...

Journal: :Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2011
Rastislav Slavkovsky Renata Kohlerova Vlasta Tkacova Alena Jiroutova Burak Tahmazoglu Vladimir Velebny Martina Rezačová Lubos Sobotka Jiri Kanta

Impaired diabetic wound healing is an important current medical issue, mainly concerning patients recovering from complicated operations or patients with ulcers on their feet. The obese Zucker diabetic fatty rat, with a mutation in leptin receptors, may be a good choice for studying impaired wound healing. Male and female rats were fed a diabetogenic high-fat diet. Wound size changes of air-exp...

2011
Charles M. Zelen Brian Stover David Nielson Muriel Cunningham

OBJECTIVE Patients with diabetes often present with pedal wounds resistant to standard wound healing modalities and become chronic in nature. These chronic wounds in diabetic patients have a high incidence of complications including infection and amputation. Negative pressure wound therapy has been found to facilitate healing of the stagnant pedal wound. This protocol was designed to determine ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Ming Gao Trung T Nguyen Mark A Suckow William R Wolter Major Gooyit Shahriar Mobashery Mayland Chang

Nonhealing chronic wounds are major complications of diabetes resulting in >70,000 annual lower-limb amputations in the United States alone. The reasons the diabetic wound is recalcitrant to healing are not fully understood, and there are limited therapeutic agents that could accelerate or facilitate its repair. We previously identified two active forms of matrix metalloproteinases (MMPs), MMP-...

Journal: :International Journal of Research in Medical Sciences 2017

Journal: :Diabetes 2001
D Altavilla A Saitta D Cucinotta M Galeano B Deodato M Colonna V Torre G Russo A Sardella G Urna G M Campo V Cavallari G Squadrito F Squadrito

Impaired wound healing is a well-documented phenomenon in experimental and clinical diabetes. Experimental evidence suggests that a defect in vascular endothelial growth factor (VEGF) regulation might be associated with wound-healing disorders. We studied the involvement of lipid peroxidation in the pathogenesis of altered VEGF expression in diabetes-related healing deficit by using an incision...

2016
Windy E. Cole

Objective: Various treatment options exist for wound healing; however, clinical assessment of the patient and the wound environment must be considered before determining an optimal wound treatment plan. Negative pressure wound therapy alone and/or with an instilled topical solution can be effective in adjunctive management of acute and chronic wounds. Hyperbaric oxygen therapy has also been sho...

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