BACKGROUND The effects of diabetes on short-term results of coronary artery bypass graft (CABG) surgery are known, but less is known about the long-term effects of diabetes and diabetic-related sequelae for patients undergoing this surgery. We studied the 10-year survival of nondiabetic and diabetic patients undergoing CABG surgery. METHODS AND RESULTS A prospective regional cohort study was ...

Institutions 1 Department of Rehabilitation Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 2 Diabetic foot clinic, Department of Surgery, Ziekenhuisgroep Twente, Almelo and Hengelo, the Netherlands. 3 Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America. 4 CIDES / CINTESIS – Health Inform...

Introduction: Investigations of preoperative oral carbohydrate (CHO) loading have primarily examined benefits among patients without diabetes. Preoperative CHO-rich beverages in general populations resulted reductions insulin resistance after surgery, protein loss, metabolic derangements, and immune dysfunction. The aim this study was to assess the effect CHO diabetic undergoing laparoscopic ch...

Diabetes is a major epidemic, and diabetic nephropathy is the most common cause of end-stage renal disease. Two critical components of diabetic nephropathy are persistent inflammation and chronic renal ischemia from widespread vasculopathy. Moreover, acute ischemic renal injury is common in diabetes, potentially causing chronic kidney disease or end-stage renal disease. Accordingly, we tested t...

The aim of this study was to determine the effect of PRP on healing of femoral cancellous bone defect in diabetic rabbit. The experiment was conducted on 20 male adult New Zealand white rabbits. After induction of diabetes rabbits were divided into two groups of control and experiment of 10 rabbits each. After general anesthesia, a hole in size of 4×5 mm in diameter and depth was made using a d...

PURPOSE To analyze the effects of a dexamethasone intravitreal implant (DEX; Ozurdex 700 μg; Allergan) administered immediately after cataract surgery in diabetic patients. METHODS This prospective, single-arm, open label study (NCT01748487 at ClinicalTrials.gov) involved Type 2 diabetic patients with at least mild diabetic retinopathy (DR) who underwent cataract surgery and DEX insertion aft...

OBJECTIVE Roux-en-Y gastric bypass (RYGB) in humans can remit type 2 diabetes, but the operative mechanism is not completely understood. In mice, fibroblast growth factor (FGF) 15 (FGF19 in humans) regulates hepatic bile acid (BA) production and can also resolve diabetes. In this study, we tested the hypothesis that the FGF19-BA pathway plays a role in the remission of human diabetes after RYGB...

Background. We investigated the effect of laparoscopic sleeve gastrectomy (LSG) on morbidly obese diabetics and examined the short-term impact of LSG on diabetic medication cost. Methods. A prospective database of consecutive bariatric patients was reviewed. Morbidly obese patients with type 2 diabetes who underwent LSG were included in the study. Age, gender, body mass index (BMI), diabetic me...

BACKGROUND The goal of salvage surgery in the diabetic foot is maximal preservation of the limb, but it is also important to resect unviable tissue sufficiently to avoid reamputation. This study aims to provide information on determining the optimal amputation level that allows preservation of as much limb length as possible without the risk of further reamputation by analyzing several predicti...

BACKGROUND Proliferative diabetic retinopathy leading to vitreous hemorrhage, tractional retinal detachment, and neovascular glaucoma is a major cause of severe sight impairment in adults of working age worldwide. Neovascular glaucoma occurs in 2.5% of patients with proliferative diabetic retinopathy, which is difficult to treat and often leads to blindness. Onset of neovascular glaucoma with r...