Müller cells are retinal glial cells and exhibit a fibroblast-like phenotype and ability to migrate in diabetic retinopathy (DR). However, expression of mesenchymal markers, which promote fibrosis in various organs, has not been characterized in the diabetic retina. We examined changes in the expression of these markers in Müller cells exposed to high glucose and in animal models of diabetic re...

The early signs of diabetic retinopathy (DR) are depicted by microaneurysms among other signs. A prompt diagnosis when the disease is at the early stage can help prevent irreversible damages to the diabetic eye. In this paper, we propose a decision support system (DSS) for automated screening of early signs of diabetic retinopathy. Classification schemes for deducing the presence or absence of ...

OBJECTIVE To evaluate the effect of uncomplicated phacoemulsification on central macular thickness (CMT) and best corrected visual acuity (BCVA) in both diabetic patients without diabetic retinopathy (DR) and diabetic patients with mild to moderate non-proliferative diabetic retinopathy (NPDR). METHODS Potential prospective observational studies were searched through PubMed and EMBASE. Standa...

RATIONALE Both insulin and IGF-1 have been implicated in the control of retinal endothelial cell growth, neovascularization and diabetic retinopathy. Recent findings have established an essential role for IGF-1 in angiogenesis and demonstrated a new target for control of retinopathy that explains why diabetic retinopathy initially increases with the onset of insulin treatment. OBJECTIVE This ...

Hyperglycemia is a key determinant for development of diabetic retinopathy (DR). Inadequate glycemic control exacerbates retinopathy, while normalization glucose levels delays its progression. In hyperglycemia, hexokinase saturated and excess metabolized to sorbitol by aldose reductase via the polyol pathway. Therapies reduce retinal accumulation prevention DR have been elusive because low dehy...

BACKGROUND Fetuin-A, a liver-derived glycoprotein, is correlated with diabetes. The aim of the present investigation was to evaluate serum and vitreous concentrations of fetuin-A in patients with diabetic retinopathy (DR). MATERIAL AND METHODS We randomly selected 224 diabetic patients and 68 control subjects for this study. RESULTS :There were markedly higher serum and vitreous fetuin-A conc...

Diabetic retinopathy (DR) classically presents with micro-aneurysms, small haemorrhages and/or lipoprotein exudates. Several studies have indicated that neural loss occurs in DR even before vascular damage can be observed. This study evaluated the possible relationship between structure (spectral domain-optical coherence tomography) and function (Rarebit visual field test) in patients with type...

Aims. This study investigated the association of autoantibodies binding to oxidized low-density lipoproteins (oxLDL) in diabetic retinopathy (DR). Methods. Plasma from 229 types 1 and 2 patients with DR including diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) was analysed with ELISA-based assay to determine IgA, IgG, and IgM autoantibody levels binding to oxLDL. The c...

Abstract Background Diabetic retinopathy (DR) is a micro-vascular consequence of diabetes mellitus (DM) that manifests clinically as retinal ischemia, neovascularization, altered permeability, and macular edema. In the adult population, DR now considered leading cause blindness. Fetuin-A multifunctional glycoprotein that, because its dual role in insulin resistance angiogenesis, could be an ear...

: Diabetes is a chronic, underlying, and common disease worldwide that imposes an enormous burden on the health system. Diabetic retinopathy (DR) serious complication in eye caused by diabetes may lead to visual impairment blindness. The knowledge about risk factors of DR critical for prevention developing treatment options. Moreover, multifactorial disease, many studies have demonstrated vario...