Beta-carotene (BC) is a precursor of vitamin A and an excellent antioxidant. It protects the vascular system. Vascular dementia (VaD) one aging disorders causing memory dysfunction. The available medicines for management VaD are limited. present study aimed to evaluate ameliorative effect BC in streptozotocin (STZ)-induced diabetic rats. Diabetic was induced through administration nicotinamide ...

A number of reports indicate that a long-chain free fatty acid export system may be operating in mitochondria. In this study, we sought evidence of its existence in rat heart mitochondria. To determine its potential role, we also sought evidence of its activation or inhibition in streptozotocin (STZ)-induced diabetic rat heart mitochondria. If confirmed, it could be a novel mechanism for regula...

Abstract This study aimed to examine the anti-diabetic effects of an unexplored medical plant Sorbaria tomentosa Lindl. Rehder using in vitro and vivo approaches. The extracts were tested as inhibitors α-glucosidase α-amylase following standard protocols. Methanolic extract was analyzed via gas chromatography-mass spectrometry (GC-MS) for tentative identification secondary metabolites. GC-MS an...

The aim of this study was to evaluate the anti-diabetic potential T. occidentalis seed extract in wistar rats. Exactly 500 g powdered sample processed into extract. Twenty five adult male rats were divided groups each. Group I normal control and fed rat chow water only, II untreated diabetic Groups III IV administered 100 200 mg/kg respectively. V standard drug (200 metformin). Administration l...

Dapagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, has been widely used in treatment of diabetic nephropathy (DN). Previous studies have shown that it both glucose-lowering effects and renoprotective functions DN. Tubulointerstitial fibrosis plays an important role the pathogenesis development progression Angiotensin‑converting enzyme (ACE2), major component renin-angiotensin sy...

Ischemia is one of the main epidemic factors and characteristics of diabetic chronic wounds, and exerts a profound effect on wound healing. To explore the mechanism of and the cure for diabetic impaired wound healing, we established a type 2 diabetic rat model. We used an 8 weeks high fat diet (HFD) feeding regimen followed by multiple injections of streptozotocin (STZ) at a dose of 10mg/kg to ...

OBJECTIVE Impaired glucose counterregulation during hypoglycemia is well documented in patients with type 1 diabetes; however, the molecular mechanisms underlying this defect remain uncertain. We reported that the inhibitory neurotransmitter γ-aminobutyric acid (GABA), in a crucial glucose-sensing region within the brain, the ventromedial hypothalamus (VMH), plays an important role in modulatin...