474 February 2014 P OSTOPERATIVE residual curarization is common after the use of muscle relaxants and may compromise patient outcome after general anesthesia.1–3 The incidence of postoperative residual curarization can be reduced by adequate neuromuscular block reversal and quantitative neuromuscular monitoring.4,5 However, in patients with severe pathologies of the peripheral nervous system, ...

Sensorimotor Polyneuropathy D iabetic neuropathy remains an unmet medical need. While scientific advances (1,2) have been made in understanding pathophysiology, the impact on the clinical care of patients has been minimal, aside from symptomatic treatments for the pain that may accompany diabetic sensorimotor polyneuropathy (DPN) (3). Improved glucose control is still the main recommendation fo...

Asymmetric periflexural exanthem (APE) is a distinctive exanthem, probably viral in origin. It is largely a disease of childhood and is uncommon in adults. We report an adult man presenting with the typical clinical findings of APE.

OBJECTIVE Mild demyelination may contribute more to the pathophysiology of nerve fiber injury in diabetic sensorimotor polyneuropathy (DSP) than previously thought. We investigated the clinical and electrodiagnostic classifications of nerve injury in diabetic patients to detect evidence of conduction slowing in DSP. RESEARCH DESIGN AND METHODS Type 1 diabetic subjects (n = 62) and type 2 diab...

Diabetic polyneuropathy is a specific form of peripheral nerve disorder, in which distal nerve axons degenerate insidiously under hyperglycemia of diabetes mellitus. Although all types of peripheral nerve fibers are involved, it is usually sensory dominant with eventual involvement of autonomic and motor nerve fibers. Its manifestation ranges from subclinical changes in nerve conduction to pain...