Neuropathic pain is an important problem because of its complex natural history, multiple possible etiologies, and poor response to standard physical therapy modalities. Disorders of the peripheral nerve system (PNS) are heterogeneous and may involve motor fibers, sensory fibers, small myelinated and unmyelinated fibers and autonomic nerve fibers, with variable anatomical distribution (single n...

Corresponding author: Min Young Chung Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-dong, Dong-gu, Gwangju 501-757, Korea E-mail: [email protected] We appreciate the interest and comments on our study, “Association between diabetic polyneuropathy and cardiovascular complications in type 2 diabetic patients,” whic...

BACKGROUND AND AIMS We undertook this study to assess the influence of diabetic peripheral neuropathy on self-reported disability and postural control during quiet stance of patients with peripheral vestibular disease, before and after a standardized program of vestibular rehabilitation (Cawthorne & Cooksey exercises). METHODS Twenty patients with peripheral vestibular disease participated in...

BACKGROUND Peroxynitrite, a product of the reaction of superoxide with nitric oxide, causes oxidative stress with concomitant inactivation of enzymes, poly(ADP-ribosylation), mitochondrial dysfunction and impaired stress signalling, as well as protein nitration. In this study, we sought to determine the effect of preventing protein nitration or increasing peroxynitrite decomposition on diabetic...

iii Acknowledgements v List of Figures xiii Chapter One: Introduction 1 1. Diabetes Mellitus 2 2. Diabetic Neuropathy 3 3. Dyslipidemia and Lifestyle Factors 6 4. Mitochondrial Dysfunction 12 5. Inflammation 15 6. Peripheral Nervous System Insulin Resistance 19 7. Exercise Intervention as a Preventative and Treatment for Diabetic Neuropathy 21 8. Study Significance 24 Chapter Two: Phenotypic Ch...

Objective: The objective of this study was to determine the prevalence yoga practice in patients with Diabetic Peripheral Neuropathy (DPN) and compare its acceptance among chronic diseases other than DPN practicing non-yoga physical activities.
 Methods: A pre-formed structured questionnaire-based cross-sectional conducted a total 98 out 240 screened recruited during face interview, diagno...

Neuropathies are among the most common of all the long-term complications of diabetes, affecting up to 50% of patients.1–5 There are many subgroups of neuropathies; readers are referred to recent reviews for discussion of the autonomic neuropathies6 and the mononeuropathies.7 This article will focus on the most common of all the peripheral neuropathies: the somatic neuropathies affecting the lo...

Recently, chemotherapy-induced peripheral neuropathy has received a great deal of attention. However, the interaction of diabetic neuropathy with potentially neurotoxic chemotherapy is far less understood. The incidence of type II diabetes has risen exponentially in the past two decades. In concert with the rise in type II diabetes, the number of individuals with diabetes who need chemotherapy ...