Diabetic foot infections are associated with significant morbidity, account for the largest number of diabetesrelated hospital bed days and contribute to 50% of all lower extremity amputations in the United States. The annual incidence of foot ulcers in diabetic patients is about 2%, which, given that there are now 15-20 million diabetics nationally, extrapolates to over 300,000 cases per year....

Various different systems have been proposed to classify diabetic foot ulcers, but none has gained widespread acceptance. The International Working Group of the Diabetic Foot (IWGDF) developed a classification system for research purposes, which is described in this report. In this PEDIS system, all foot ulcers should be classified according to five categories: perfusion, extent/size, depth/tis...

OBJECTIVE Diabetic foot infection is the predominant predisposing factor to nontraumatic lower-extremity amputation (LEA), but few studies have investigated which specific risk factors are most associated with LEA. We sought to develop and validate a risk score to aid in the early identification of patients hospitalized for diabetic foot infection who are at highest risk of LEA. RESEARCH DESI...

The diabetic foot syndrome is clearly one of the most important complications of diabetes and is the most common cause of hospitalization among diabetic patients. Staphylococcus aureus is found to be the commonest pathogen present in diabetic foot infections. The aim of the present study is to determine activities of three kinds of antibiotics against Staphylococcal biofilm and planktonic cultu...

In this longitudinal study of 1666 persons with diabetes, there was an observed trend toward an increased risk for amputation (chi(2) test for trend, 108.0; P<.001), higher-level amputation (chi(2) test for trend, 113.3; P<.001), and lower extremity-related hospitalization (chi(2) test for trend, 118.6; P<.001) with increasing infection severity. The Infectious Diseases Society of America's foo...

BACKGROUND Diabetic foot ulcers contribute significantly to the morbidity and mortality of patients with diabetes mellitus. The diabetic patients with foot ulcers require long hospitalisation and carry risk of limb amputation. The risk factors for developing diabetic foot ulcers are manageable. In Kenya there is paucity of data on such risk factors. OBJECTIVE To determine the prevalence of di...

OBJECTIVES Appropriate antimicrobial therapy and surgical intervention may be required in diabetic patients presenting with severe bacterial foot infection. Methicillin-resistant Staphylococcus aureus (MRSA) agents such as fosfomycin are increasingly in demand because of recent concern regarding vancomycin and daptomycin efficacy and constant use. Intravenous fosfomycin is approved for the ther...

BACKGROUND Diagnosis of infection in diabetic foot ulcer (DFU) is not always simple. The analytic precision of procalcitonin (PCT) was evaluated to clarify the use of PCT for distinguish the presence of infection in DFU in comparison to other inflammatory markers. MATERIALS AND METHODS This study comprised 88 subjects distributed into four groups: 16 nondiabetic healthy subjects (group contro...

D espite improved treatment, a significant number of diabetic foot ulcers do not heal and eventually lead to amputation (1–5). The important local factors determining the healing rate of ulcers are pressure at the site of the ulcer, adequacy of blood supply, and infection. It is generally accepted that for optimal healing, infection needs to be treated. However, the definition of infection is a...

introduction:we evaluated the performance of muscle perfusion scan (mps) to assess muscle perfusion reserve (mpr) for prediction of incident diabetic foot ulcerations (dfu). methods: we recruited 41 diabetic patients without any history of dfu. five mci 99mtc-mibi was injected intravenously during repetitive dorsal and plantar right foot flexions. then posterior calves were imaged and the count...