The study's objectives were to investigate nuclear stereology and to determine the level of p62, a protein involved in nuclear transport, in human cardiomyocytes from patients with heart failure due to ischemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM). We studied 23 human hearts: 10 had ICM, 10 had DCM, and three were from control subjects. The size of the nucleus was significantly ...

Cardiomyopathy is an important cause of heart failure in Sub-Saharan Africa, accounting for up to 30% of adult heart failure hospitalisations. This high prevalence poses a challenge in societies without access to resources and interventions essential for disease management. Over 80 genes have been implicated as a cause of cardiomyopathy. Mutations in the phospholamban (PLN) gene are associated ...

Cardiomyopathy is one of the major causes of sudden death and/or progressive heart failure. Dilated cardiomyopathy (DCM), comprising 60% of the cases of identified cardiomyopathy, is the most common form of heart muscle disease. Interleukin 17 (IL-17) is a proinflammatory cytokine that has been implicated in the pathogenesis of various diseases. To evaluate the influence of IL-17A and IL-17F ge...

BACKGROUND Myocardial fibrosis is an essential hallmark of diabetic cardiomyopathy (DCM) contributing to cardiac dysfunctions. Resveratrol, an antioxidant, exerts its anti-fibrotic effect via inhibition of oxidative stress, while the underlying molecular mechanism remains largely elusive. Periostin, a fibrogenesis matricellular protein, has been shown to be associated with oxidative stress. In ...

Background and objectives Patients with Dilated Cardiomyopathy (DCM) and Hypertrophic Cardiomyopathy (HCM) frequently demonstrate non-ischemic pattern myocardial fibrosis (MF) on delayed enhancement magnetic resonance imaging (DE-MRI). The clinical significance of this finding with respect to impact on Quality of Life (QOL) is poorly understood. In this study we identify the prevalence of MF in...

Diastolic dysfunction is an increasingly recognized complication of diabetes that develops in relatively young patients as a result of diabetic cardiomyopathy (DCM). With recent advances in echocardiographic technology now permitting the reliable assessment of diastolic function in the rat, we examined cardiac function and structure in diabetic rodents and assessed the effects of intervening wi...

Background—Increased levels of tumor necrosis factor-a (TNF-a) and inducible nitric oxide synthase (iNOS) have been reported in patients with dilated cardiomyopathy. We investigated the myocardial expression of TNF-a and iNOS in patients with HIV-associated cardiomyopathy (HIV-DCM) compared with patients with idiopathic dilated cardiomyopathy (IDCM). Methods and Results—Endomyocardial biopsy sp...

Andrew Maslow MD Department of Anesthesiology Rhode Island Hospital, Providence Rhode Island Introduction Cardiomyopathy is generally defined as a “disease of the myocardium associated with cardiac dysfunction”. 1 Primary cardiomyopathies are divided into three major classifications: a) dilated cardiomyopathy (DCM), b) hypertrophic cardiomyopathy (HCM), and c) restrictive (or infiltrative) card...

Unlike other parts of the world in which cardiomyopathy is rare, heart muscle disease is endemic in Africa. The major forms of cardiomyopathy in Africa are dilated cardiomyopathy (DCM) and endomyocardial fibrosis (EMF). Whereas DCM is a major cause of heart failure throughout the continent, EMF is restricted to the tropical regions of East, Central, and West Africa. Although epidemiological stu...

Diabetes mellitus is a progressive systemic disease that adversely affects cardiovascular function. Diabetesassociated cardiovascular changes are a major cause of morbidity and mortality worldwide. Clinical trials indicate that diabetes accelerates and worsens the prognosis of coronary atherosclerosis, is associated with a 3-fold increase in the incidence of heart failure and that it is indepen...