Andrographolide (ADG) is a diterpenoid isolated from Andrographis paniculata with a wide spectrum of biological activities, including anti-inflammatory, anticancer and hepatoprotective effects. However, its poor water solubility and efflux by P-glycoprotein have resulted in lower bioavailability. In this study, ADG nanosuspensions (ADG-NS) were prepared using a wet media milling technique follo...

Introduction: The amount of expression of BAX and BCL-2 genes in infertile men’s sperm as well as its association with sperm parameters and DNA fragmentation index is an issue which has not been studied yet. In this research, it is assumed that up-regulation of BAX and downregulation of BCL-2 are directly associated with sperm DNA fragmentation. Methods: After obtaining semen samples from the ...

Chlorophyll-a fluorescence adalah perpendaran cahaya yang dilepaskan oleh klorofil untuk membuang kelebihan energi foton diterima dari sinar matahari pada proses fotosintesa. Salah satu parameter turunan chlorophyll-a Performance Index (PI). PI menggambarkan informasi kualitatif mengenai kebugaran tanaman. Pengamatan saat kondisi normal, tercekam kekeringan moderat, dan parah memungkinkan pengh...

Dependency graphs such as call and data usage graphs are often used to study software systems and perform impact analysis during maintenance activities. These graphs show the present structure of the software system (e.g. In a compiler, an Optimizer function calling a Parser function). They fail to reveal details about the structure of the system that are needed to gain a better understanding. ...

BACKGROUND This case-control study was designed with the aim of evaluating the role of sperm, oxidative stress and DNA damage in idiopathic recurrent pregnancy loss (iRPL). This pilot study is the first study done on the Indian population which reports the association between DFI, TAC and ROS in couples experiencing iRSA. METHODS Twenty infertile men with a history of iRPL and 20 fertile cont...

Background Atopic dermatitis (AD) is detrimental to the infants' and their families' quality of life. We aimed to study the disease effects on Iranian infants and their familiesapplying theinfants’ dermatitis quality of life index (IDQOL), and the dermatitis family impa...

PURPOSE Skeletal muscle metastases (SMM) from non-small cell lung cancer (NSCLC) are rarely encountered in clinical practice. The prognosis and the adequate treatment are not known. The aim of the study was to report our experience and to make an extensive literature research concerning SMM. PATIENTS AND METHODS In our unit, we identified 16 patients with SMM in a 10-year period. The source o...

Traditional routine semen analysis and biochemical assays are insufficient for the determination of fertility status in individual men. In recent years, clinical evidence has shown that damaged human sperm DNA may adversely affect assisted reproductive outcomes and that the spermatozoa of infertile men possess substantially more DNA damage than the spermatozoa of fertile men. In this study, we ...

BACKGROUND The sperm chromatin structure assay (SCSA) provides an objective assessment of sperm chromatin integrity, which is essential for normal sperm function. SCSA is valuable as a fertility marker in epidemiological studies and in the clinical situation. Little is known about the impact of testicular and post-testicular function on SCSA parameters. METHODS Ejaculates from 278 military co...

BACKGROUND Due to satisfactory cytoreductive surgery combined with platinum-based chemotherapy in epithelial ovarian cancer has improved greatly, however, the relapse rate also high. In current study, we analyzed prognostic factors related to secondary cytoreductive surgery in patients with recurrent epithelial ovarian cancer. METHODS Clinical and follow-up data from 103 patients with recurre...