ABSTFACT Prostaglandin E (PGE1) sensitive adenylate cyclase rEC.4.6.1.1 ATP-pyrophosphaie lyase (cyclizing)] in human platelet lysates is inhibited by dextran sulfate. Inhibition is dose-dependent at the range of l-10 ug/ml. Maximal inhibition obtained was 85% at 30 ug/ml . At a similar range of concentrations dextran sulfate was found to antagonize the anti-aggregating effect of PGEl on adenos...

The anomalous increase in charge selectivity as previously observed with reduced dextran sulfate clearances in diabetic rats (L. D. Michels, M. Davidman, and W. F. Keane. Kidney Int. 21: 699-705, 1982) was confirmed in 4-wk streptozotocin (STZ) diabetic Sprague-Dawley rats using the isolated perfused kidney technique. The apparent charge selectivity in both control and diabetic rats could be ab...