نتایج جستجو برای: dex

تعداد نتایج: 3951  

Journal: :Fukushima journal of medical science 2015
Shinju Obara Issei Morimoto Yuzo Iseki Rieko Oishi Midori Mogami Tsuyoshi Imaizumi Atsushi Hosono Takahiro Hakozaki Yuko Nakano Tsuyoshi Isosu Masahiro Murakawa

We carried out a retrospective investigation on the effect of obesity on dexmedetomidine (DEX) requirements when administered with fentanyl (FEN) during mechanical ventilation after major surgeries. After Institutional Review Board approval, 14 obese patients with a body mass index (BMI) ≥ 30 kg/m(2) and the same number of non-obese patients with similar backgrounds to the obese patients were s...

Journal: :The American journal of physiology 1999
Norma A Bobadilla Edilia Tapia Fabiola Jiménez Laura G Sánchez-Lozada José Santamaría Alberto Monjardín Alexis Bolio Gerardo Gamba Jaime Herrera-Acosta

Cyclosporin A (CsA)-induced renal vasoconstriction (RV) is attributed to an imbalance in vasoactive factors release. Dexamethasone (Dex) exerts a renal vasodilatory effect by a mechanism not yet characterized. This study evaluates whether the effect of Dex is mediated by NO and whether it prevents CsA-induced RV. Micropuncture studies were performed in six groups of uninephrectomized rats treat...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2002
Lucy C Sullivan Sandra Orgeig Christopher B Daniels

Pulmonary surfactant is a mixture of lipids and proteins that controls the surface tension of the fluid lining the inner lung. Its composition is conserved among the vertebrates. Here we hypothesize that the in ovo administration of glucocorticoids and thyroid hormones during late incubation will accelerate surfactant development in the saltwater crocodile, Crocodylus porosus. We also hypothesi...

2016
Andrew McWilliam

At a bulge latitude of b = −4◦, the average [Fe/H] and [Mg/H] values are +0.06 and +0.17 dex, roughly 0.2 and 0.7 dex higher than the local thin and thick disk values, respectively, suggesting a large bulge effective yield, perhaps due to efficient retention of supernova ejecta. The bulge vertical [Fe/H] gradient, at ∼0.5 dex/kpc, appears to be due to a changing mixture of sub-populations (near...

Journal: :The Journal of Experimental Medicine 1983
F Ivars G Nyberg D Holmberg A Coutinho

The isotype distribution of Dextran B 512 (Dex)-specific plaque-forming cells (PFC) and serum antibodies was studied after in vivo immunization in C57BL/6 mice. Although IgG2b and IgG3 could also be detected in most individuals, the majority of non-IgM PFC were of the IgA isotype. All classes other than IgM were T cell-dependent, as shown by their complete absence in athymic "nude" mice. This u...

Journal: :Investigative ophthalmology & visual science 2011
Weiming Mao Tara Tovar-Vidales Thomas Yorio Robert J Wordinger Abbot F Clark

PURPOSE To determine whether perfusion-cultured bovine anterior segments would be a suitable model for glaucoma research. METHODS Fresh bovine eyes were dissected and sealed on a custom-made acrylic dish with an O-ring. Perfusion medium was infused by a syringe pump at a constant infusion rate of 5 μL/min. After intraocular pressure (IOP) was stable, bovine eyes were perfused with medium cont...

2011
Nesrine Z Mostafa Hasan Uludağ Mathew Varkey Douglas N Dederich Michael R Doschak Tarek H El-Bialy

BACKGROUND AND OBJECTIVE Periodontitis is an inflammatory disease causing bone loss, and is a primary cause of tooth loss. Gingival fibroblasts are readily available with minimal donor site morbidity and may be ideal for tissue engineering efforts in regenerating lost alveolar bone. Dexamethasone (Dex) is commonly employed for in vitro osteogenic induction of a variety of cells, but its effect ...

2018
Guo-Rong He Xiao-Kun Lin Yong-Biao Wang Cong-De Chen

Dexmedetomidine (DEX) a type of the anaesthetic that has been widely used in anaesthesia and intensive care. However, whether DEX affects the pharmacokinetics of drugs remains elusive. As hepatic P‑glycoprotein (P‑gp) serves a critical role in the disposition of drugs, the present study aimed to address whether P‑gp function could be affected by DEX in vitro. In the present study, L02 cells (a ...

2015
Jingmou Yu Yunfeng Zhou Wencong Chen Jin Ren Lifang Zhang Lu Lu Gan Luo Hao Huang

In the present study, α-tocopherol succinate (TOS) conjugated dextran (Dex-TOS) was synthesized and characterized by fourier transform infrared (FT-IR) spectroscopy, ¹H nuclear magnetic resonance (¹H NMR), dynamic light scattering (DLS) and fluorescence spectroscopy. Dex-TOS could form nanoscaled micelles in aqueous medium. The critical micelle concentration (CMC) is 0.0034 mg/mL. Doxorubicin (...

2015
Jun-Qing Situ Yi-Qing Ye Xiu-Liang Zhu Ri-Sheng Yu Jian You Hong Yuan Fu-Qiang Hu Yong-Zhong Du

The delivery of chemotherapeutics into tumor cells is a fundamental knot for tumor-target therapy to improve the curative effect and avoid side effects. Here, A54 peptide-functionalized poly(lactic-co-glycolic acid)-grafted dextran (A54-Dex-PLGA) was synthesized. The synthesized A54-Dex-PLGA self-assembled to form micelles with a low critical micelle concentration of 16.79 μg·mL(-1) and diamete...

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