BACKGROUND Liver transplantation is nowadays the only effective answer to adjourn the outcome of functional limitations associated with familial amyloidotic polyneuropathy (FAP), a neurodegenerative disease characterized by sensory and motor polyneuropathies. Nevertheless, there is a detrimental impact associated with the after-surgery period on the fragile physical condition of these patients....

Exercise during growth is widely recommended as a key strategy in the primary prevention of osteoporosis. This theory seems reasonable if exercise is pursued into adulthood, but perhaps not if exercise is ceased; in the latter case, the mechanostat theory predicts a decrease in bone strength due to a decrease in the largest forces applied to the skeleton. However, recent findings suggesting mai...

Repeated strenuous exercise while breathing cold air is believed to induce chronic airway inflammation and hyperreactivity, a condition referred to in humans as ‘ski asthma’. However, the time course of development and resolution of ski asthma is unknown. We have previously shown that multi-day aerobic exercise induces airway inflammation and hyperreactivity in racing sled dogs. In the present ...

Physical education (PE) teachers carry out resistance training programs at the beginning of a school year so that children can do other tasks safely during the whole course. However, after a few weeks of detraining, children revert back to their initial strength level. The purpose of this study was to evaluate the effects of a maintenance resistance training program on muscular strength in chil...

The study aimed to verify the pattern of critical load (CL) and anaerobic swim capacity (ASC) during a twelve-week continuous program, after 3 and 9 days of detraining, and in a short-term retraining in swimming rats. Animals were distributed into four groups: control (CG), trained (TG), detrained 3 days (D3G) and detrained 9 days (D9G). They were submitted to a CL test in a swimming exercise. ...

The effects of detraining subsequent to strength training on neuromuscular function were examined in 39 recent-onset rheumatoid arthritis (RA) patients. Eighteen age- and sex-matched healthy people (H) served as controls. Patients were randomly allocated either to the experimental group (PE), who carried out progressive strength training for 6 months, or to the control group (PC), who maintaine...

As it is a common observation that obesity tends to occur after discontinuation of exercise, we investigated how white adipocytes isolated from the periepididymal fat of animals with interrupted physical training transport and oxidize glucose, and whether these adaptations support the weight regain seen after 4 weeks of physical detraining. Male Wistar rats (45 days old, weighing 200 g) were di...

The effects of endurance training on the water compartments and the cardiovascular system were determined in 10 elderly subjects [age 62 +/- 2 yr, pretraining maximal oxygen consumption (VO2 max)/kg = 25 +/- 2 ml . min-1 . kg-1 body wt]. They trained on a cycloergometer 3 times/wk for 16 wk (50-80% VO2 max, then 80-85% VO2 max). They were checked at 8 wk, 16 wk, and 4 mo after detraining. Train...