Abstract Background Long noncoding RNAs (lncRNAs) play important roles in various biological and pathological processes. Discovery of lncRNA–protein interactions (LPIs) contributes to understand the functions mechanisms lncRNAs. Although wet experiments find a few between lncRNAs proteins, experimental techniques are costly time-consuming. Therefore, computational methods increasingly exploited...

background: given the increasing importance of suspended particles and reporting weather conditions in the amount of ultraviolet radiation in many countries, in this study, the data of the maximum amounts of pollution by suspended particles with the size of 10, 2.5 and1 microns (pm10, pm2.5, pm1) which were reported in 1-hour time-series and global ultraviolet index (uvi) were used to predict t...

Shiga toxin (Stx), an AB5 toxin, binds specifically to the neutral glycosphingolipid Gb3 at the cell surface before being transported into cells. We here demonstrate that addition of conical lysophospholipids (LPLs) with large head groups inhibit Stx binding to cells whereas LPLs with small head groups do not. Lysophosphatidylinositol (LPI 18:0), the most efficient LPL with the largest head gro...

Femtosecond fluorescence upconversion and transient absorption experiments have been performed to monitor the photoinduced electronic, geometry, and solvent relaxation dynamics of 1,8-bis(dimethylamino)naphthalene dissolved in methylcyclohexane or n-hexane, n-dodecane, dichloromethane, and acetonitrile. The data have been analyzed by using a sequential global analysis method that gives rise to ...

The solute carrier family 7A member 7 gene (SLC7A7) encodes the light chain of the heterodimeric carrier responsible for cationic amino acid (CAA) transport across the basolateral membranes of epithelial cells in intestine and kidney. Mutations affecting SLC7A7 cause lysinuric protein intolerance (LPI), a multiorgan disorder with clinical symptoms that include visceromegaly, growth retardation,...

Several studies attempt to describe changes in the spatial patterns of forests over time, resorting to the comparison of landscape pattern indices (LPI), but new methods for quantifying landscape differences in a statistical context are necessary. In this paper, we quantified and assessed the statistical significance of the forests pattern changes, which have occurred since the end of WWII in C...

the contamination of riverbed sediments by heavy metals has assumedserious problems due to their toxicity and accumulative behavior. the present studyinvestigated the concentrations of heavy metals from the bottom sediments of shitalakhyariver to understand the level of contamination and their distribution. the averageconcentrations of heavy metals al, k, ca, mg, fe, as, cu, co, cr, and zn are ...

Lysinuric protein intolerance (LPI) is an inborn error of metabolism which usually presents in infancy with failure to thrive and vomiting. Two patients are described who presented in adult life with hyperammonaemic coma due to LPI. Both had been underweight and had had intermittent gastrointestinal symptoms during childhood. They were of normal intellect and had maintained good health, until p...

Using data from 1387 lakes collected over three decades, we found a wide range in the concentrations of total phosphorus (TP), total nitrogen (TN) and chlorophyll in Florida lakes, and that edaphic factors as outlined by the USEPA’s Florida Lake Regions were the dominant factor in determining the concentrations of plant nutrients in the state’s lakes. The hypothesis that all eutrophic lakes in ...

The cannabinoid receptor 1 (CB(1)) and CB(2) cannabinoid receptors, associated with drugs of abuse, may provide a means to treat pain, mood, and addiction disorders affecting widespread segments of society. Whether the orphan G-protein coupled receptor GPR55 is also a cannabinoid receptor remains unclear as a result of conflicting pharmacological studies. GPR55 has been reported to be activated...