A woman in the care of the author 40 years ago was reported to have been sleeping for 2 days. We treated her condition as conversion hysteria. Her private psychiatrist was the renowned R. D. Laing; he was unhappy with our line of management, on the grounds of the arbitrariness of the diagnosis, the labelling of the woman with a diagnosis of hysteria and the treatment of the patient without her ...

An aldol condensation and an Algar-Flynn-Oyamada oxidative cyclization were key steps in the direct synthesis of chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.

The first total synthesis of pandamarilactone-1, an alkaloid of Pandanus amaryllifolius, is reported. The nine-step synthesis features furan oxidation with singlet oxygen and then spiro-N,O-acetalization and elimination to generate the natural product and further Pandanus alkaloids, pandamarilactonines A-D.

The synthesis of 4-amino-3-cyano-N-arylpyrazoles A based on a Thorpe-Ziegler cyclization as the key step has been achieved using microwave activation. Via a new diversity-oriented synthetic pathway, these highly functionalized building blocks allowed the access to various heteroaromatic scaffolds such as pyrazolo-pyridines B, pyrazolo-pyrimidines C and pyrazolo-oxadiazoles D. Interestingly, the...

The chemical structure of the new angucycline antibiotic landomycin A has been elucidated via chemical and spectroscopic methods, in particular by 2D NMR correlation spectroscopy, e.g., 1H, 1H-COSY, 13C, 1H-COSY, correlation spectroscopy via long-range-couplings and heteronuclear multiple bond connectivity spectroscopy sequences. The spectroscopic investigations were carried out principally wit...

Ustiloxin D and phomopsin A are potent antimitotic agents that bind to tubulin and interfere with cellular microtubule function. A synthetic strategy has been developed to allow access to both of the natural products as well as a variety of variants of the ustiloxin and phomopsin family members in order to provide sufficient quantities for biological studies. Herein we report the enantioselecti...

Jean Guy LeBlanc and Svetoslav Dimitrov Todorov a Centro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, C.P. T4000ILC, San Miguel de Tucumán, Tucumán, Argentina b Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, Departamento de Alimentos e Nutrição Experimental, Laboratório de Microbiologia de Alimentos, Av. Prof. Lineu Prestes 580 Bloco 14, 05508-000, São Paulo...

In [5], D. Lanphier used differential operators studied by Maass [6] to prove the above van der Pol identity (2). He also obtained several van der Pol-type identities using the Maass operators and thereby obtained new congruences for the Ramanujan’s tau-function. In [9], D. Niebur derived a formula for τ(n) similar to the classical ones of Ramanujan and van der Pol, but has the feature that hig...

diethylaminoethylamino 4 methyl 10 thiaxanthenone (Miracil D, Niodin, lucanthone) has a wide spectrum of carcinostatic effectiveness against a variety of mouse tumors at nontoxic dosage levels (5). One of the most responsive tumors was leukemia L1210 ascites, a test sys tem which has proven relatively refractory to carcino static agents in general (3). The mechanism of action of this drug, whic...

Chairman: Y. Thomassen (Norway); Members: J. Aaseth (Norway); G. Alfthan (Finland); D. Behne (FRG); H. A. Das (Netherlands); H. T. Delves (UK); R. M. Griffin (USA); M. Ihnat (Canada); V. Iyengar (FRG); 0. A. Levander (USA); Mirna Mikac-Devic (Yugoslavia); J. Pikkarainen (Finland); Marion F. Robinson (New Zealand); M. Stoeppler (FRG); Christine D. Thomson (New Zealand); R. T. Tulley (USA); C. Ve...