BACKGROUND Clinical epidemiology research studies, including pharmacoepidemiology and pharmacovigilance studies, use routinely collected health data, such as diagnoses recorded in national health and administrative registries, to assess clinical effectiveness and safety of treatments. We estimated positive predictive values (PPVs) of International Classification of Diseases, 10th revision (ICD-...

Adjuvant high dose IVIgs are being used increasingly in a range of immune-mediated and auto-immune diseases. Although numerous immunomodulatory mechanisms have been suggested, the exact mechanisms of action are poorly understood. The efficacy of IVIg in certain diseases has been proven in clinical trials, in so far as IVIg is approved as the therapy of choice for Kawasaki syndrome and idiopathi...

Pruritus, a frequent complaint heard by family physicians, is a complex physiological phenomenon mediated by histamine and other peptides. It is associated with a number of common dermatologic diseases but has significant psychological factors as well. In some patients pruritus may be an important marker of systemic disease. Diagnostic approach includes a careful physical examination of primary...

Introduction The antiphospholipid antibody syndrome (APS) is a multisystemic autoimmune disease characterized by thromboembolic events, pregnancy morbidity, hematologic, dermatologic, neurologic and other manifestations in the presence of elevated titers of antiphospholipid antibodies (aPL). In recent years, APS has been increasingly recognized in various pediatric autoimmune and nonautoimmune ...

Nitric oxide (NO) plays multiple roles in both normal and abnormal skin processes. Its deranging disbalance is involved the pathogenesis of dermatologic diseases such as acne vulgaris, pointing towards beneficial therapeutic directions. A novel NO-producing gel-formulation was tested treatment vulgaris an open-label pilot study using clinical evaluation scores. It showed a decrease comedones in...

Epidermal growth factor receptor inhibitors (EGFRIs) are a treatment option for patients diagnosed with advanced-stage gastrointestinal, lung, and head and neck cancers. The most prevalent complications associated with EGFRIs are dermatologic toxicities, which may result in either disruption or discontinuation of treatment and adversely affect patients' quality of life. Nurses play a vital role...

BACKGROUND Although rarely life threatening, dermatological diseases may have a considerable influence on a patient's quality of life and psychological well-being. As with morbidity and mental distress from other chronic diseases, a skin disorder can be the one of the main causes of depression in the geriatric population. OBJECTIVE To determine the prevalence of depression in elderly patients...

What must be known about cosmetic dermatology procedures nowadays? We are witnessing an increase in the number of persons who visit beauticians, dermatologists, and plastic surgeons, hoping to improve their appearance. Considering surgery procedures for wrinkling, there are pros and cons. Beauty becomes a standard for human quality of life and professional attention is focused not only on " rea...

BACKGROUND AND AIMS Dermatology consultation occurs mainly in the outpatient setting. The reasons for inpatient dermatologic consultation by other specialties in a hospital, its frequency and its impact on health care are largely unrecorded. METHODS We retrospectively studied the records of 971 hospitalized patients or patients being evaluated in emergency services for which a dermatologist's...