نتایج جستجو برای: derived neurotrophic

تعداد نتایج: 486570  

2000
Bronwen Connor Martha C. Bohn

Abbreviations: GDNF, glial cell line-derived neurotrophic factor; BDNF, brain-derived neurotrophic factor; DA, dopaminergic; 6-OHDA, 6-hydroxydopamine; Ad, adenoviral; SN, substantia nigra pars compacta; CNS, central nervous system; MFB, medial forebrain bundle; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP+, 1-methyl-4-phenyl pyridinium; MAO-B, monoamine oxidase; TH, tyrosine hydroxy...

Journal: :Russian Open Medical Journal 2022

Coronary artery disease (CAD) is defined as myocardial damage developing a result of its organic and functional changes, leading to impaired blood flow through the coronary arteries. An important pathogenetic component CAD atherosclerosis. Currently, key aspects molecular relationship between inflammation atherosclerosis are being actively studied, immunometabolic theory discussed, along with a...

Journal: :International Journal of Medical Sciences 2012

Journal: :American Journal of Respiratory Cell and Molecular Biology 2016

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Takayuki Harada Chikako Harada Shinichi Kohsaka Etsuko Wada Kazuhiko Yoshida Shigeaki Ohno Hiroshi Mamada Kohichi Tanaka Luis F Parada Keiji Wada

Activation of microglia commonly occurs in response to a wide variety of pathological stimuli including trauma, axotomy, ischemia, and degeneration in the CNS. In the retina, prolonged or high-intensity exposure to visible light leads to photoreceptor cell apoptosis. In such a light-reared retina, we found that activated microglia invade the degenerating photoreceptor layer and alter expression...

Journal: :The European journal of neuroscience 2004
Irina V Nosrat Christopher A Smith Patrick Mullally Lars Olson Christopher A Nosrat

Glial cell line-derived neurotrophic factor (GDNF) mRNA is highly expressed by dental pulp cells (DPCs) prior to the initiation of dental pulp innervation. We show that radioactively labelled exogenous GDNF is retrogradely transported from neonatal teeth and vibrissae to the trigeminal neurons, indicating that GDNF acts as a classical neurotrophic factor in the trigeminal system. We also show t...

2013
Sherry L. Xu Cathy W. C. Bi Roy C. Y. Choi Kevin Y. Zhu Abudureyimu Miernisha Tina T. X. Dong Karl W. K. Tsim

Neurotrophic factors are playing vital roles in survival, growth, and function of neurons. Regulation of neurotrophic factors in the brain has been considered as one of the targets in developing drug or therapy against neuronal disorders. Flavonoids, a family of multifunctional natural compounds, are well known for their neuronal beneficial effects. Here, the effects of flavonoids on regulating...

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