Effects of some selective serotonergic (5-HT) antagonists on methamphetamine-induced anorexia were investigated in male mice. The least possible dose of methamphetamine alone that caused significant anorectic activity was 11 micromolkg(-1), i.p. (2 mgkg(-1)). Various doses of some selective serotonergic receptor antagonists were administered half an hour before the above mentioned dose of metha...

Interpretation of urine drug-testing results is a challenging endeavor for several reasons. Effects of pH, dilution, legitimate and illicit sources of the drugs, and, perhaps the most challenging, the possibility of the methamphetamine and/or amphetamine being the result of the use of some other drug. Although it is known that 14 different compounds are metabolized to methamphetamine or ampheta...

OBJECTIVES Methamphetamine use is a strong risk factor for stroke. This study was designed to evaluate arterial function and structure in methamphetamine users ultrasonographically. METHODS In a cross-sectional study, 20 methamphetamine users and 21 controls, aged between 20 and 40years, were enrolled. Common carotid artery intima-media thickness (CCA-IMT) marker of early atherogenesis, flow-...

results patients reported that their use of methamphetamine was motivated by methadone’s side effects and encouraged by family and friends who promoted methamphetamine use to assuage the side effects of methadone in the early stages of treatment before the appearance of methadone maintenance therapy’s effects on their life. patients and methods to gain a better understanding of patients’ motiva...

Capillary electrophoresis using β-cyclodextrin and dimethyl-β-cyclodextrin as chiral selectors was performed in parallel to gas chromatography-mass spectrometry, in an effort to characterize the enantiomeric substances in 557 illicit methamphetamine tablets in Thailand collected during 1983-2000. The study revealed the stimulants in these tablets, namely ephedrine, methamphetamine and caffeine,...

1. The effect of methamphetamine on morphine-dependent mice was investigated by calculating the LD50 (i.p.), measuring motor activity, anorectic actions, and body temperature. 2. Methamphetamine was more toxic in morphine-dependent mice (LD50 = 20.6 mg/kg) than in normal mice (LD50 = 43.2 mg/kg). 3. Methamphetamine-induced locomotor activity was greater in morphinized than in nonmorphinized mic...

In mid-1995, a government effort to reduce the supply of methamphetamine precursors successfully disrupted the methamphetamine market and interrupted a trajectory of increasing usage. The price of methamphetamine tripled and purity declined from 90 percent to 20 percent. Simultaneously, amphetaminerelated hospital and treatment admissions dropped 50 percent and 35 percent, respectively. Methamp...

AIM To investigate the safety and efficacy of once-daily supervised oral administration of sustained-release dexamphetamine in people dependent on methamphetamine. DESIGN Randomized, double-blind, placebo-controlled trial. PARTICIPANTS Forty-nine methamphetamine-dependent drug users from Drug and Alcohol Services South Australia (DASSA) clinics. INTERVENTION Participants were assigned ran...

Introduction: Craving to methamphetamine is a significant health concern and exposure to methamphetamine cues in laboratory can induce craving. In this study, a task designing procedure for evaluating methamphetamine cue-induced craving in laboratory conditions is examined.

Chronic methamphetamine use poses potentially devastating consequences for directly affected individuals and for society. Lower dopamine D2-type receptor availability has been observed in striata of methamphetamine users as compared with controls, but an analogous comparison of D1-type receptors has been conducted only on post-mortem material, with no differences in methamphetamine users from c...