The effect of sodium depletion on the dose-response relationships of angiotensin II to aldosterone and blood pressure was studied. Arterial plasma angiotensin II and aldosterone and arterial blood pressure were measured before and during the incremental infusion of angiotensin II into sodium-replete and sodium-deplete subjects. Sodium depletion caused a distinct steepening of the angiotensin H-...

[1] The effect of ozone depletion on temperature trends in the tropical lower stratosphere is explored with an atmospheric general circulation model, and directly contrasted to the effect of increased greenhouse gases and warmer sea surface temperatures. Confirming and extending earlier studies we find that, over the second half of the 20th Century, the model’s lower-stratospheric cooling cause...

ABSTACT Human hepatocellular carcinoma (HCC) is known to have a poor prognosis. Sorafenib, a molecular targeted drug, is most commonly used for HCC treatment. However, its effect on HCC is limited in clinical use and therefore new strategies regarding sorafenib treatment are required. Iron overload is known to be associated with progression of chronic hepatitis and increased risk of HCC. We pre...

The effect of sodium depletion on the dose-response relationships of angiotensin II to aldosterone and blood pressure was studied. Arterial plasma angiotensin II and aldosterone and arterial blood pressure were measured before and during the incremental infusion of angiotensin II into sodium-replete and sodium-deplete subjects. Sodium depletion caused a distinct steepening of the angiotensin H-...

Previous studies have shown that the interaction of positive and inhibitory signals plays a crucial role during lung branching morphogenesis. We found that in mesenchyme-free conditions, the lung epithelium exerted a lateral inhibitory effect on the neighbouring epithelium via depletion of fibroblast growth factor 1 (FGF1). Contrary to previous suggestions, bone morphogenetic protein 4 could no...

It is well known that glucose is a major energy source in tumors and that mitochondria are specialized organelles required for energy metabolism. Previous studies have revealed that nitric oxide (NO) protects against glucose depletion-induced cytotoxicity in mouse liver cells and in rat hepatocytes, but the detailed mechanism is not well understood. Therefore, we investigated the involvement of...

Consumer choices are a result of an interplay of two systems: fast and intuitive thinking (System 1) and more deliberative reasoning (System 2). The present research examines the implication of the interplay between the two systems for context effects in choice by exploring the consequences of resource depletion. Building on a substantial body of psychological literature that points to one unde...

The effect of the administration of androgens (testosterone and dihydrotestosterone(, antiandrogens (progesterone and cyproterone acetate) and anabolic steroids (Bolandiol, Nandrolone, Furazabol and Methenolone) on depletion and replenishment of the androgen receptor in the cytosol of ventral prostate from castrated rats was examined using 3H-R1881 as the ligand. Administration of androgens lea...

The rate at which the Earth’s surface receives high-utility energy from the Sun is 11,000 times as great as the rate at which humans use commercial energy. Despite this, 88 percent of the commercial energy used comes from non-renewable, fossil-fuel sources. Fossil fuel use each year adds 3 percent more carbon-dioxide to the atmosphere than natural sinks can remove. The task for humans is to fin...

Seasonal turbidity patterns and event-level hysteresis analysis of turbidity verses discharge in four 1 km headwater catchments in California’s Sierra Nevada indicate localized in-channel sediment sources and seasonal accumulation-depletion patterns of stream sediments. Turbidity signals were analyzed for three years in order to look at the relationships between seasonal turbidity trends, event...