The bioavailability of nitric oxide is decreased in animal models and humans with diabetes mellitus. Hyperglycemia, in particular, attenuates endothelium-dependent vasodilation in healthy subjects. In vitro and in vivo animal studies implicate activation of protein kinase Cbeta as an important mechanism whereby hyperglycemia decreases endothelium-derived nitric oxide. Accordingly, this study te...

The bioavailability of nitric oxide is decreased in animal models and humans with diabetes mellitus. Hyperglycemia, in particular, attenuates endothelium-dependent vasodilation in healthy subjects. In vitro and in vivo animal studies implicate activation of protein kinase C as an important mechanism whereby hyperglycemia decreases endothelium-derived nitric oxide. Accordingly, this study tested...

33 Spaceflight has profound effects on vascular function as a result of weightlessness that 34 may be further compounded by radiation exposure. The purpose of the present study was 35 to assess the individual and combined effects of hindlimb unloading (HU) and radiation 36 (Rad) on vasodilator responses in the skeletal muscle vasculature. Adult male C57BL/6J 37 mice were randomized to one of fo...

Endothelial dysfunction is characterized by abnormalities in vasoreactivity and is a marker of the extent of atherosclerosis. Cellular repair by circulating progenitor cells of ongoing vascular injury may be essential for vascular integrity and function and may limit abnormalities in vasoreactivity. Apolipoprotein E-deficient (apoE-/-) mice were splenectomized and treated with high-cholesterol ...