Dengue is the most important vector-borne disease in the Americas and threatens the lifes of millions of people in developing countries. Imprecise morbidity and mortality statistics underestimate the magnitude of dengue as a regional health problem. As a result, it is considered a low priority by the health sector with no timely steps for effective control. Dengue is perceived as a problem of '...

Various simple mathematical models have been used to investigate dengue transmission. Some of these models explicitly model the mosquito population, while others model the mosquitoes implicitly in the transmission term. We study the impact of modeling assumptions on the dynamics of dengue in Thailand by fitting dengue hemorrhagic fever (DHF) data to simple vector-host and SIR models using Bayes...

This study considers the dengue occurrence in the city of Belo Horizonte over the last fifteen years. Approximately 186,000 cases registered from 1996 to 2011 were analyzed. The home address of individuals whose dengue case was notified was used as a proxy for exposure location. For determining possible outbreaks of disease and the specific patterns of dengue cases, spatial statistics used incl...

The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) was formed to evaluate the safety of live, recombinant viral vaccines incorporating genes from heterologous viruses inserted into the backbone of another virus (so-called "chimeric virus vaccines"). Many viral vector vaccines are in advanced clinical trials. The first such vaccine to be approved for marketing (to date...

The mosquito Aedes albopictus (Ae. albopictus) is a vector of dengue virus in southeast Asia. However, it is most notable for its accidental introductions into and subsequent colonisation of new areas. Ae. albopictus importations, primarily via used tyres infested with eggs, have been documented in the United States of America, Europe and Australia. The vector has become established in the sout...

Vector-borne diseases particularly those transmitted by mosquitoes like Dengue are among the leading causes of mortality and morbidity in human population. There are no effective vaccines or treatment against dengue fever till date and the control methods are limited. So, new approaches are urgently in need to reverse these trends. Vector control is currently the primary intervention tool. Stra...

In north Queensland the vector of dengue fever (Aedes aegypti) is present; hence any viraemic individual importing dengue has the potential to transmit the disease locally. In early 2000 approximately 2,000 personnel returned from East Timor to Townsville, north Queensland. Seven importations of dengue occurred and individual cases were viraemic for up to 6 days in Townsville. No subsequent loc...

Plasmodium and dengue virus, the causative agents of the two most devastating vector-borne diseases, malaria and dengue, are transmitted by the two most important mosquito vectors, Anopheles gambiae and Aedes aegypti, respectively. Insect-bacteria associations have been shown to influence vector competence for human pathogens through multi-faceted actions that include the elicitation of the ins...

INTRODUCTION This study investigated the knowledge of users of primary healthcare services living in Ribeirão Preto, Brazil, about dengue and its vector. METHODS A cross-sectional survey of 605 people was conducted following a major dengue outbreak in 2013. RESULTS Participants with higher levels of education were more likely to identify correctly the vector of the disease. CONCLUSIONS Th...

BACKGROUND The World Health Organization estimates that the global number of dengue infections range between 80-100 million per year, with some studies estimating approximately three times higher numbers. Furthermore, the geographic range of dengue virus transmission is extending with the disease now occurring more frequently in areas such as southern Europe. Ae. aegypti, one of the most promin...